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Improving parasitism success of a weakly virulent parasitoid strain.
J Insect Physiol
December 2024
EGCE, Université Paris-Saclay, CNRS, IRD, UMR Évolution, Génomes, Comportement et Écologie, Gif-sur-Yvette 91190, France. Electronic address:
Endoparasitoids possess a whole set of virulence factors to counter the immune response of their host, among which can be found venom, endosymbiotic viruses and ovarian proteins. Depending on the species, some factors are expected to be less necessary than others. Notably, venom is reported as inessential in some parasitoids bearing viruses.
View Article and Find Full Text PDFThe retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni.
Nucleic Acids Res
December 2024
Institute of Parasitology, Justus Liebig University, Schubertstrasse 81, 35392 Giessen, Germany.
Studies on transcription regulation in platyhelminth development are scarce, especially for parasitic flatworms. Here, we employed single-cell transcriptomics to identify genes involved in reproductive development in the trematode model Schistosoma mansoni. This parasite causes schistosomiasis, a major neglected infectious disease affecting >240 million people worldwide.
View Article and Find Full Text PDFCocktail vaccine for the management of and .
Front Immunol
December 2024
Entomology Laboratory, Division of Parasitology, Indian Council of Agricultural Research (ICAR)- Indian Veterinary Research Institute (IVRI)-Izatnagar, Bareilly, Uttar Pradesh, India.
Introduction: Globally, ticks rank second only to mosquitoes as vectors of deadly pathogens affecting humans and first in transmitting animal pathogens, presenting a significant challenge to human wellness and sustainability of livestock-based industries. Traditional tick control via chemical acaricides impacts on the environment and has led to the emergence of multi-acaricide-resistant tick populations. Use of immunoprophylactic, along with other components of integrated tick management, holds the potential to mitigate tick infestations in a sustainable manner.
View Article and Find Full Text PDFYellow grub diseases on two seasonal killifish (Cyprinodontiformes, Rivulidae): a histopathological study.
Parasitol Res
November 2024
Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada (LHYEDEC), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata (UNLP), La Plata, Buenos Aires, Argentina.
Article Synopsis
- Yellow grub disease, caused by the parasite Clinostomum spp., affects the muscles and organs of freshwater fish, particularly killifishes in the Neotropical region, which are already vulnerable due to their short lifespan.
- * The study investigates the inflammatory damage caused by this parasite in various organs of two killifish species, revealing severe reactions especially in the pancreas, ovaries, and testes.
- * The findings suggest that this parasitic infection could lead to low fertility or sterility in seasonal killifishes, greatly affecting their ability to reproduce before their habitats dry up.
Multicomponent syntheses enable the discovery of novel quisinostat-derived chemotypes as histone deacetylase inhibitors.
Eur J Med Chem
January 2025
Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, 53121, Bonn, Germany. Electronic address:
In this study, we synthesized and evaluated novel histone deacetylase (HDAC) inhibitors derived from the clinical candidate quisinostat. A library of 16 compounds categorized in three novel chemotypes was rapidly generated using multicomponent reactions (MCRs), enabling efficient structure-activity relationship studies. First, the compounds were evaluated for their activity against the Plasmodium falciparum strains 3D7 and Dd2, the main malaria-causing parasite, identifying compound 18b of the type C series as the most potent.
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