Clinical and predictive value of 24-hour blood pressure rhythm is reviewed. Insufficient nocturnal blood pressure lowering induces augmented pressure load on target organs. On the other hand it reflects dysregulatory changes due to target-organ involvement. Lack of adequate nocturnal blood pressure lowering is considered by some investigators as independent risk factor of target-organ damage. This dictates necessity of registration of parameters of 24-hour blood pressure profile in evaluation of patients with hypertension.
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