AI Article Synopsis
- The study investigates the role of polyamines (putrescine, spermidine, and spermine) in breast cancer, highlighting their connection to apoptosis and clinical outcomes in Egyptian patients.
- The research shows that polyamine levels are significantly higher in breast cancer tissues compared to benign lesions, suggesting their potential as biomarkers.
- Additionally, the findings indicate that polyamines not only correlate with cancer severity but may also serve as therapeutic targets to promote cell death in malignant tissues.
Article Abstract
Objectives: The polyamines putrescine, spermidine, and spermine, play an important role in cell proliferation, differentiation, and transformation. The aim of this study is to correlate the polyamines with apoptosis and clinico-pathologic events in Egyptian breast cancer patients.
Methods: PUT, SPD, and SPN were investigated using thin layer chromatography (TLC) and apoptosis in fresh frozen tissue specimens obtained from 40 patients suffering from breast cancer, as well as 20 patients with benign breast lesions.
Results: The levels of PUT, SPD, and SPN were higher in breast cancer tissues than in benign breast lesions (p < 0.001). Polyamines were correlated well with apoptosis. Moreover, PUT was an independent prognostic factor for relapse. Also, SPD and SPN correlated significantly with early tumor grades. ROC curves were used to choose the best cut-off values for polyamines (70, 135, and 290 mmol/g tissue) for PUT, SPD, and SPN, respectively. At these cut-off values, the sensitivities were (75%, 60%, and 70%), and the specificities were (80%, 95%, and 95%) for PUT, SPD, and SPN, respectively.
Conclusion: Polyamines may be used as additional markers for detection of malignant transformation in breast tissue. Moreover, because of their ability to induce apoptosis in malignant tissues, polyamines are suitable targets for therapeutic intervention that is specifically directed to induce apoptosis.
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| http://dx.doi.org/10.1016/s0009-9120(02)00360-0 | DOI Listing |
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