Two different methods have been derived and implemented for simulation of multipole imaging systems and aberration correctors. The first method uses an aberration theory for combinations of multipole lenses and deflectors, including primary and secondary aberrations up to the fifth order. A damped least-squares algorithm is used to minimise the dynamically correctable aberrations. This yields the appropriate signals for the dynamic correction elements, e.g. stigmators and dynamic focus lenses. The second method uses a direct ray-tracing approach. The numerically computed multipole lens and deflection fields are fitted with analytic functions through which trajectories are directly traced with a high degree of self-consistency. By computing the paths of many particles simultaneously, the combined effects of aberrations and discrete Coulomb interactions are accurately simulated. Furthermore, the effects of electrical and mechanical asymmetries on the multipole elements can readily be simulated with this approach.
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Brain Stimul
January 2025
Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA, USA, 01609; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA; Department of Mathematics, Worcester Polytechnic Institute, Worcester, MA, USA, 01609.
Neuroimage
February 2025
Dept. of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
A fast BEM (boundary element method) based approach is developed to solve an EEG/MEG forward problem for a modern high-resolution head model. The method utilizes a charge-based BEM accelerated by the fast multipole method (BEM-FMM) with an adaptive mesh pre-refinement method (called b-refinement) close to the singular dipole source(s). No costly matrix-filling or direct solution steps typical for the standard BEM are required; the method generates on-skin voltages as well as MEG magnetic fields for high-resolution head models within 90 s after initial model assembly using a regular workstation.
View Article and Find Full Text PDFBrain Stimul
December 2024
Department of Electrical and Computer Eng., Worcester Polytechnic Inst., Worcester, MA, USA; Department of Mathematical Sciences, Worcester Polytechnic Inst., Worcester, MA, USA.
Background: Modeling brain stimulation at the microscopic scale may reveal new paradigms for various stimulation modalities.
Objective: We present the largest map to date of extracellular electric field distributions within a layer L2/L3 mouse primary visual cortex brain sample. This was enabled by the automated analysis of serial section electron microscopy images with improved handling of image defects, covering a volume of 250 × 140 × 90 μm³.
Bioengineering (Basel)
October 2024
Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
Electroencephalographic (EEG) source localization is a fundamental tool for clinical diagnoses and brain-computer interfaces. We investigate the impact of model complexity on reconstruction accuracy by comparing the widely used three-layer boundary element method (BEM) as an inverse method against a five-layer BEM accelerated by the fast multipole method (BEM-FMM) and coupled with adaptive mesh refinement (AMR) as forward solver. Modern BEM-FMM with AMR can solve high-resolution multi-tissue models efficiently and accurately.
View Article and Find Full Text PDFNano Lett
December 2024
School of Electrical Engineering, Korea University, Seoul 02841, Republic of Korea.
The significance of antireflection has persisted over time due to its numerous optical applications. To achieve broadband antireflection, multiple element-based designs using graded-index films or multiresonant nanostructures have been conventionally employed. In this work, we propose an additional degree of freedom in developing antireflection by manipulating the orientation angles of nanostructures to achieve the symmetry-dependent Kerker condition.
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