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Comparative Genomics and Biosynthetic Cluster Analysis of Antifungal Secondary Metabolites of Three Strains of Isolated from Rhizospheric Soils.
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Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala S/N, Mexico City CP 11430, Mexico.
is a genus of Gram-positive bacteria with high GC content. It remains attractive for studying and discovering new antibiotics, antifungals, and chemotherapeutics. genomes can contain more than 30 cryptic and expressed biosynthetic gene clusters (BGC) encoding secondary metabolites.
View Article and Find Full Text PDFMulti-Objective Optimization Accelerates the De Novo Design of Antimicrobial Peptide for .
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Department of Chemical Engineering & Institute of Biotechnology Engineering and Chemical Engineering, I-Shou University, Kaohsiung 824005, Taiwan.
Humans have long used antibiotics to fight bacteria, but increasing drug resistance has reduced their effectiveness. Antimicrobial peptides (AMPs) are a promising alternative with natural broad-spectrum activity against bacteria and viruses. However, their instability and hemolysis limit their medical use, making the design and improvement of AMPs a key research focus.
View Article and Find Full Text PDFThe Combination of Resveratrol and Conjugated Linoleic Acid Dienes Enhances the Individual Effects of These Molecules on De Novo Fatty Acid Biosynthesis in 3T3-L1 Adipocytes.
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Department of Human Nutrition and Dietetics, University of Agriculture, Balicka 122, 30-149 Kraków, Poland.
Consuming food containing ingredients with a documented impact on lipid metabolism can help fight overweight and obesity. The simplest way to reduce the level of fatty acids is to block their synthesis or increase the rate of their degradation. This study aimed to determine the effect of resveratrol, , conjugated linoleic acid (CLA), , CLA, and various variants of their combinations on de novo fatty acid biosynthesis in 3T3-L1 adipocytes.
View Article and Find Full Text PDFInhibiting De Novo Biosynthesis of Ceramide by L-Cycloserine Can Prevent Light-Induced Retinal Degeneration in Albino BALB/c Mice.
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Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Retinal degenerative diseases lead to irreversible vision loss due to photoreceptor cell death, driven by complex genetic and environmental factors. Ceramide, a sphingolipid metabolite, emerges as a critical mediator in the apoptotic cascade associated with retinal degeneration. Our previous work demonstrated L-Cycloserine's ability to protect photoreceptor-derived cells from oxidative stress by inhibiting the de novo ceramide pathway and thus prompting further investigation on its effect in the in vivo retina.
View Article and Find Full Text PDFDepletion of Gibberellin Signaling Up-Regulates Transcription and Promotes Adventitious Root Formation in Leaf Explants.
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Jiangxi Provincial Key Laboratory of Plant Germplasm Innovation and Genetic Improvement, Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang 332900, China.
Adventitious root (AR) formation in plants originates from non-root organs such as leaves and hypocotyls. Auxin signaling is essential for AR formation, but the roles of other phytohormones are less clear. In , at least two distinct mechanisms can produce ARs, either from hypocotyls as part of the general root architecture or from wounded organs during de novo root regeneration (DNRR).
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