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Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNA production.
Proc Natl Acad Sci U S A
January 2025
Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892.
Mitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG deficiency causes mitochondrial dysfunction. However, the mechanism by which EndoG regulates mitochondrial function is not known.
View Article and Find Full Text PDFFeasibility study of using next-generation reservoir computing (NG-RC) model to estimate liver tumor motion from external breathing signals.
Med Phys
December 2024
Department of Energy Engineering and Physics, Amirkabir University of Technology, Tehran, Iran.
Background: Respiratory motion is a challenge for accurate radiotherapy that may be mitigated by real-time tracking. Commercial tracking systems utilize a hybrid external-internal correlation model (ECM), integrating continuous external breathing monitoring with sparse X-ray imaging of the internal tumor position.
Purpose: This study investigates the feasibility of using the next generation reservoir computing (NG-RC) model as a hybrid ECM to transform measured external motions into estimated 3D internal motions.
Wireless wearable multifunctional sensor based on carboxylated cellulose nanofibers/silver nanowires for ultra-sensitive, fast humidity response and body temperature monitoring.
Int J Biol Macromol
December 2024
Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, No. 100, Daxuedong Road, Xixiangtang District, Nanning 530004, China. Electronic address:
Humidity and temperature sensors are considered as hotspots for the next generation of wearable multifunctional electronics. However, it is still a notable challenge to realize multifunctional sensors with high-performance humidity response, excellent mechanical properties, and accurate temperature monitoring capability. In this work, a hydrogen-bond cross-linked hybrid network was constructed between carboxystyrene-butadiene rubber (XSBR) and hydrophilic carboxylated cellulose nanofibers (CNF) noncovalently modified silver nanowires (AgNWs).
View Article and Find Full Text PDF-CoFeO/TiCT/BNC Hybrid Aerogels with Modulation Impedance Matching for Electromagnetic Wave Absorption and Health Monitoring.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Advanced Materials for Facility Agriculture, Ministry of Agriculture, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Given the limitations of single-function electromagnetic wave-absorbing materials (EWAMs) in meeting the evolving demands of complex usage scenarios, there is a growing need for structure-function integrated composites that offer a combination of microwave absorption, human monitoring, and thermal insulation. This study successfully synthesized two-dimensional (2D) TiCT MXene via selective etching of Al from the TiAlC MAX phase. By introducing MXene into a composite of hydroxylated CoFeO nanoparticles (-CFO NPs) and bacterial nanocellulose (BNC) to modulate the electromagnetic performance of the EWAMs.
View Article and Find Full Text PDFMETTL4-Mediated Mitochondrial DNA N6-Methyldeoxyadenosine Promoting Macrophage Inflammation and Atherosclerosis.
Circulation
December 2024
Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University, China. (L.Z., X.C., X.H., Y.T., J.M., Xinyu Li, H.W., M.C., Y.Z., M.D., Q.Y., D.H., H.J., Xuesong Li, H.C.).
Background: Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA). However, the role of METTL4-mediated mitoepigenetic regulation in atherosclerosis is still unknown.
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