From a cohort of 110 idiopathic clubfeet, 26 feet in 18 children requiring surgery for severe relapse have been studied. Surgery comprised a lateral column shortening procedure (Lichtblau) plus or minus a plantarmedial release. Surgery was staged to avoid wound complications. Preoperatively feet were prospectively categorized, according to a system reported by Dimeglio, into one of four grades. This grading system provides a clinical assessment. Children were reviewed on two subsequent occasions. At review feet were again graded and in addition appearance and functional outcome were analysed. This included an assessment of gait, activity and functional limitation. Three children were lost to follow-up leaving 22 feet in seven male and eight female patients available for review. The mean age at surgery was 43 months (23-82 months). The mean time from surgery to first and second reviews was 35 and 56 months respectively. There was a significant improvement in grading at first review compared with preoperative grading (Wilcoxon signed ranks test). Although there remained a significant improvement in grading at second review compared with the preoperative grading, there was a significant reduction in the number of feet in which grading had improved when compared with first review. There was no significant change in function between the two postoperative reviews, with the majority of children experiencing little functional limitation. There were no wound complications. We conclude that relapse surgery, involving a lateral column shortening procedure for severe clubfoot, results in a significant initial improvement when assessed using a grading system. This improvement in grading subsequently decreases over time. However, the functional outcome in such cases remains favourable.
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http://dx.doi.org/10.1097/01.bpb.0000043567.17315.a4 | DOI Listing |
Sci Rep
December 2024
Department of Urology, The Jikei University School of Medicine, Kashiwa Hospital, Kashiwashita 163-1, Kashiwa, Chiba, 277-8567, Japan.
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December 2024
Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK.
Network hypersynchrony is emerging as an important system-level mechanism underlying seizures, as well as cognitive and behavioural impairments, in children with structural brain abnormalities. We investigated patterns of single neuron action potential behaviour in 206 neurons recorded from tubers, transmantle tails of tubers and normal looking cortex in 3 children with tuberous sclerosis. The patterns of neuronal firing on a neuron-by-neuron (autocorrelation) basis did not reveal any differences as a function of anatomy.
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December 2024
Potsdam University of Applied Sciences, Kiepenheuerallee 5, 14469, Potsdam, Germany.
Persuasive appeals frequently prove ineffective or produce unintended outcomes, due to the presence of motivated reasoning. Using the example of electric cars adoption, this research delves into the impact of emotional content, message valence, and the coherence of pre-existing attitudes on biased information evaluation. By conducting a factorial survey (N = 480) and incorporating a computational model of attitude formation, we aim to gain a deeper insight into the cognitive-affective mechanisms driving motivated reasoning.
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December 2024
Department of Neurosurgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No.1678, Dongfang Road, Pudong District, Shanghai, China.
This study investigated the prevalence and severity of lower urinary tract symptoms (LUTS) in children with spastic cerebral palsy (SCP) and evaluated the effect of selective dorsal rhizotomy (SDR) in alleviating these symptoms. The study also explored the correlation between postoperative LUTS improvement and intraoperative electrophysiological findings. Prospective data were collected from a consecutive cohort of 247 children with SCP who underwent SDR and were retrospectively analyzed.
View Article and Find Full Text PDFBAY 2413555 is a novel selective and reversible positive allosteric modulator of the type 2 muscarinic acetylcholine (M2) receptor, aimed at enhancing parasympathetic signaling and restoring cardiac autonomic balance for the treatment of heart failure (HF). This study tested the safety, tolerability and pharmacokinetics of this novel therapeutic option. REMOTE-HF was a multicenter, double-blind, randomized, placebo-controlled, phase Ib dose-titration study with two active arms.
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