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http://dx.doi.org/10.1097/00004836-200301000-00026 | DOI Listing |
Langmuir
January 2025
School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, Jiangsu 211189, P. R. China.
This study aims to improve the signal-to-noise ratio (SNR) of chemiluminescence immunoassay (CLIA) by increasing the amount of protein immobilized on the surface of the magnetic bead (MB). Proteins are macromolecules with three-dimensional structures, and merely increasing the density of functional groups on the two-dimensional surface of the MB cannot significantly enhance protein immobilization. Therefore, we grafted spatially extended functional polymer to not only increase the density of functional groups on the MB surface but also expand their distribution in three-dimensional space, ultimately increasing protein immobilization.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Urology, People's Hospital of Deyang City, Chengdu University of Traditional Chinese Medicine, Deyang, China.
Objective: The high hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been reported to be a good prognostic indicator for several malignancies. However, more evidence is needed before it can be introduced into clinical practice. Here, we systematically evaluated the predictive value of HALP for survival outcomes in patients with solid tumors.
View Article and Find Full Text PDFCureus
December 2024
Department of General Medicine, Father Muller Medical College, Bangalore, IND.
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that imposes significant complications, including diabetic peripheral neuropathy (DPN). DPN is characterized by marked inflammation, and the fibrinogen-to-albumin ratio (FAR) is one of the new markers for systemic inflammation, it has been used in various diabetic micro- and macro-vascular complications. The present study investigates the association between FAR and nerve conduction abnormalities in T2DM patients with DPN.
View Article and Find Full Text PDFZhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.
Objective: To investigate the correlation of the clinical characteristics, fever characteristics, serum biomarkers with cytokine release syndrome (CRS) in patients with relapsed/refractory multiple myeloma (R/R MM) treated with chimeric antigen receptor T cell (CAR-T) immunotherapy.
Methods: 104 R/R MM patients who received CAR-T cell therapy at the Affiliated Hospital of Xuzhou Medical University from June 2017 to November 2021 were included, and the correlations of their clinical characteristics, fever characteristics, serum biomarkers with the severity of CRS were analyzed.
Results: Among 104 R/R MM patients receiving CAR-T treatment, no CRS was observed in 8 cases (7.
Am J Kidney Dis
December 2024
Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
Rationale & Objective: Afamin is a vitamin E-binding glycoprotein primarily expressed in liver and kidney. This study investigated whether serum afamin concentrations are associated with kidney function and incident kidney failure.
Study Design: Prospective cohort study with 6.
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