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Case report: Additional grounds for tighter regulation? A case series of five women with zolpidem dependence from a Brazilian women-specific substance use disorder outpatient service.
Front Psychiatry
December 2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Instituto de Psiquiatria, São Paulo, Brazil.
Objective: This study presents a case series of five women with zolpidem dependence treated at the Drug Dependent Women Treatment Center (PROMUD), one of the first women-specific substance use disorder outpatient services in Latin America.
Methods: This was an retrospective review of medical records of patients with a diagnosis of zolpidem dependence at the Institute of Psychiatry of Clinics Hospital of University of São Paulo between December 2021 and December 2023. Description of the cases followed the Case Report Statement, Checklist and Guidelines (CARE).
A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.
Explor Res Clin Soc Pharm
December 2024
College of Pharmacy, Dalhousie University, Halifax, NS, Canada.
Article Synopsis
- * A scoping review examined driving performance assessments related to BZRA use, analyzing 183 studies that featured various drugs, with zopiclone being the most researched.
- * Results showed that a significant number of studies found impairment in driving performance, with an emphasis on using certain measures like the Standard Deviation of Lateral Position (SDLP) in experimental settings, and biological detection methods in observational studies.
Assessment of Potential Drug-Drug Interactions of Psycholeptics and Antidepressants in Outpatient Settings.
Pharmacy (Basel)
November 2024
Department of Clinical Pharmacy, University Hospital Dubrava, 10 000 Zagreb, Croatia.
Article Synopsis
- - Mental health issues are becoming more prevalent, necessitating careful management of psychotropic medications in outpatient settings to prevent potentially harmful drug interactions.
- - A study analyzed 492 outpatient cases, revealing an average of 1.64 prescribed psychotropic drugs and an alarming 2.2 potential drug-drug interactions (pDDIs) per patient, with about 47.6% involving psychotropics.
- - Younger patients (under 65) were found to receive more psychotropic medications, and key drugs involved in interactions included benzodiazepines, promazine, and zolpidem, highlighting the need for pharmacists to intervene and enhance patient safety.
Clinical applications of small-molecule GABAR modulators for neurological disorders.
Bioorg Chem
December 2024
Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China. Electronic address:
Gamma-aminobutyric acid type A receptor (GABAR) modulators are crucial in treating neurological and psychiatric disorders, including epilepsy, anxiety, insomnia, and depression. This review examines the synthetic approaches and clinical applications of representative small-molecule GABAR modulators. Benzodiazepines, such as Diazepam, are well-known positive allosteric modulators (PAMs) that enhance GABAR function, providing therapeutic effects but also associated with side effects like sedation and dependence.
View Article and Find Full Text PDFResidual next-day effects of alprazolam on psychomotor performance and simulated driving in healthy normal adults.
Exp Clin Psychopharmacol
November 2024
Center on Drug and Alcohol Research, University of Kentucky.
The prevalence of drugged driving has increased in the United States. Some drugged driving may be unintentional as prescription medications used as sleeping aids, like zolpidem, cause impairment after the predicted duration of therapeutic action has elapsed. The aim of this study was to determine if nighttime administration of alprazolam, a drug commonly prescribed off-label as a sleeping aid, impacts driving performance the following day.
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