We report a case of late-onset pulmonary fibrosis involving the upper lobes that occurred in a young man treated with bleomycin for mediastinal germ-cell carcinoma. The parenchymal lesions became clinically apparent about two years after chemotherapy had been completed, with a slowly progressive course and sparing the lower lung fields during follow-up. Other possible diagnoses could be excluded on the basis of the patient's clinical history, laboratory tests and pathological findings.
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Betulin and L. bulbs extract attenuate pulmonary fibrosis by down regulating pro-fibrotic and pro-inflammatory cytokines in bleomycin-induced fibrosis mice model.
Heliyon
June 2023
Department of Pharmacology, Kwame Nkrumah University of Science and Technology, Ghana.
Article Synopsis
- Pulmonary fibrosis (PF) is a serious lung disease that leads to scarring and significantly reduces survival rates, with an average life expectancy of 3-5 years after diagnosis.
- Bleomycin (BLM) is a chemotherapy drug that can induce pulmonary fibrosis, while extracts from *L. bulbs* (CAE) and betulin (BET) have shown potential in treating this condition by reducing inflammation and collagen levels.
- In a study with mice, both CAE and BET treatments increased survival rates and significantly decreased pro-fibrotic and pro-inflammatory cytokine levels compared to those induced by BLM, suggesting their effectiveness in managing PF.
The longitudinal and regional analysis of bleomycin-induced pulmonary fibrosis in mice by microcomputed tomography.
Heliyon
May 2023
State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510000, China.
Introduction: Microcomputed tomography (micro-CT) is powerful for assessment of the progression of lung fibrosis in animal model, but current whole lung analysis (WLA) methods are time-consuming. Here, a longitudinal and regional analysis (LRA) method was developed to assess fibrosis easily and quickly by micro-CT.
Method: Firstly, we investigated the distribution pattern of lesions in BLM-induced pulmonary fibrosis mice.
[In-vivo Evaluation of Bleomycin-induced Lung Fibrosis Model Mouse Using Ultra High-field 7 T-MRI and Micro-CT].
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November 2021
Department of Medical Physics and Engineering, Area of Medical Imaging Technology and Science, Division of HealthSciences, Osaka University Graduate School of Medicine.
Purpose: This study aimed to perform longitudinal observation using 4D-computed tomography (CT) and compare images acquired by 3D-CT and 3D-ultrashort echo time (UTE) for evaluation of bleomycin-induced lung fibrosis model.
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J Invest Dermatol
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Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Fibroblasts (Fbs) are critical to hypertrophic scar (HTS) formation and were recently shown to be highly heterogeneous. However, Fb heterogeneity in HTSs has not been fully elucidated. In this study, we observed an increased fraction of CD39 Fbs in HTS after screening four Fb subtypes (CD26, CD36, FAP, and CD39).
View Article and Find Full Text PDFRole for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice.
Toxicol Pathol
July 2021
Immunity, Inflammation and Disease Laboratory, 6857National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA.
Mucin-5AC (MUC5AC) is a major secreted mucin in pathogenic airways. To determine its role in mucus-related airway disorders, -deficient () and wild-type () mice were compared in bleomycin-induced pulmonary fibrosis, respiratory syncytial virus (RSV) disease, and ozone toxicity. Significantly greater inflammation and fibrosis by bleomycin were developed in lungs compared to lungs.
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