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Copeptin as biomarker for acute ischemic stroke prognosis and revascularization treatment efficacy.
Front Neurol
December 2024
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Introduction: Pro-arginine vasopressin consists of three peptides: . AVP is released by the neurohypophysis in response to increased plasma osmolality, decreased blood volume and stress. Copeptin has the advantage of being stable ex vivo and easy to measure.
View Article and Find Full Text PDFEffect of vasopressin on brain and cardiac tissue during neonatal cardiopulmonary resuscitation of asphyxiated post-transitional piglets.
Resusc Plus
January 2025
Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada.
Background: Epinephrine is currently the only recommended cardio-resuscitative medication for use in neonatal cardiopulmonary resuscitation (CPR), as per consensus of science and treatment recommendations. An alternative medication, vasopressin, may be beneficial, however there is limited data regarding its effect on cardiac and brain tissue following recovery from neonatal CPR.
Aim: To compare the effects of vasopressin and epinephrine during resuscitation of asphyxiated post-transitional piglets on cardiac and brain tissue injury.
New cardiovascular biomarkers in patients with advanced cancer - A prospective study comparing MR-proADM, MR-proANP, copeptin, high-sensitivity troponin T and NT-proBNP.
Eur J Heart Fail
November 2024
Department of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany.
Article Synopsis
- Traditional cardiovascular biomarkers like hsTnT and NT-proBNP are crucial for monitoring cardiac function and prognosis in cancer patients, but newer biomarkers such as MR-proADM, copeptin, and MR-proANP may provide better predictive power.
- A study involving 442 hospitalized cancer patients showed that while several biomarkers predicted all-cause mortality, only MR-proADM remained a significant independent predictor after adjusting for various factors.
- MR-proADM demonstrated the highest predictive accuracy, with a specific cutoff of 0.94 nmol/L signaling a higher risk of mortality, particularly in older patients with advanced cancer stages and poorer overall health.
PTSD Increases Risk for Hypertension Development Through PVN Activation and Vascular Dysfunction in Sprague Dawley Rats.
Antioxidants (Basel)
November 2024
Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49931, USA.
This study investigates the impact of single prolonged stress (SPS), a model of post-traumatic stress disorder (PTSD), on cardiovascular responses, hypothalamic paraventricular nucleus (PVN) activity, and vascular function to elucidate the mechanisms linking traumatic stress to hypertension. Although SPS did not directly cause chronic hypertension in male Sprague Dawley (SD) rats, it induced acute but transient increases in blood pressure and heart rate and significantly altered the expression of hypertension-associated genes, such as vasopressin, angiotensin II type 1 receptor (AT1R), and FOSL1 in the PVN. Notably, mitochondrial reactive oxygen species (mtROS) were predominantly elevated in the pre-autonomic regions of the PVN, colocalizing with AT1R- and FOSL1-expressing cells, suggesting that oxidative stress may amplify sympathetic activation and stress responses.
View Article and Find Full Text PDFDisengagement of somatostatin neurons from lateral septum circuitry by oxytocin and vasopressin restores social-fear extinction and suppresses aggression outbursts in Prader-Willi syndrome model.
Biol Psychiatry
October 2023
Institut de Génomique Fonctionnelle, University of Montpellier, INSERM, CNRS, France. Electronic address:
Article Synopsis
- The study investigates how the symptoms of social signal processing in Prader-Willi Syndrome (PWS) can be influenced by neuropeptides oxytocin (OXT) and vasopressin (AVP), particularly focusing on their effects in the lateral septum (LS) of the brain.
- It uses a mouse model with a knockout of the Magel2 gene, employing various experimental techniques to observe the role of OXT and AVP in social-fear situations and identify neuronal pathways involved.
- The findings reveal that deficits in OXT and AVP signaling lead to disrupted social-fear responses by affecting certain inhibitory neurons in the LS, providing insights that could pave the way for new treatment strategies for autism spectrum disorders.
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