While the existence of the trough effect is unquestioned, its theoretical significance is unknown. A multifaceted instrumental approach - spectrographic, cineradiographic, and vocal tract modeling - was used to document the trough effect in open (V.CV) and closed (VC.V) syllable forms using a symmetrical vowel context surrounding labial stops. Collectively, the results document the trough phenomenon as a momentary deactivation of tongue and/or lip movement after V1 and continuing into the stop closure. This empirical event suggests a segment-by-segment activation pattern as opposed to a diphthongal vowel-to-vowel trajectory with an independent and superimposed consonantal gesture. Quantitative models of VCV coarticulation must incorporate the trough effect in order to more effectively capture the kinematic properties of speech.
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http://dx.doi.org/10.1159/000068349 | DOI Listing |
Heliyon
November 2024
Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Effective management of brucellosis in human populations is closely tied to controlling the disease in domestic livestock. This study focused on identifying determinants of brucellosis prevalence in mixed industrial dairy and beef cattle farms within Isfahan Province, Iran. Employing a case control design, we compared 32 ranches with documented brucellosis within the previous year (12 months) to 38 farms with no brucellosis during the same timeframe.
View Article and Find Full Text PDFESMO Open
December 2024
Department of Pharmacology, Gustave Roussy, Villejuif, France.
Nefrologia (Engl Ed)
December 2024
Department of Nephrology, Puerta del Mar University Hospital, Cádiz, Spain.
Introduction: In kidney transplant (KT) recipients diabetes mellitus (DM) are associated with an increased mortality and a poorer graft survival. Glucagon-like peptide 1 receptor agonists (GLP1-RA) have demonstrated cardiovascular and renal benefits in the general population. However, there is lacking evidence in KT recipients.
View Article and Find Full Text PDFPediatr Neonatol
November 2024
Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia; College of Pharmacy, King Saud Bin Abdulaziz University for Health Science, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Background: Tacrolimus is an essential immunosuppressive medication in paediatric patients' post-liver transplantation. Achieving tacrolimus target concentration in early post-transplantation is crucial to minimise the risk of acute rejection; however, this is challenging due to inter- and intra-patient variability in tacrolimus metabolism and clearance. Therefore, our study aims to describe tacrolimus trough concentration variability and pharmacokinetics in paediatric post-liver transplantation during the first two weeks post-transplantation.
View Article and Find Full Text PDFJ Glaucoma
December 2024
Department of Ophthalmology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
Prcis: Automated optic nerve head hemoglobin measurements through change overtime in the Globin Individual Pointer (GIP) index, provided by the Laguna ONhE software, can be useful to evaluate structural progression in glaucoma.
Purpose: To assess the performance of automated optic nerve head hemoglobin measurements (ONH Hb) for detection of structural progression in glaucoma patients using event analysis.
Patients And Methods: Treated glaucoma patients were included in this cross-sectional study.
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