AI Article Synopsis
- Prodigiosin (PG) is a bacterial-derived compound that has been found to trigger apoptosis (programmed cell death).
- In a study using Jurkat cells, researchers observed that PG activated key enzymes called caspases-9, -8, and -3, which are involved in the apoptotic process, indicated by the presence of their cleavage products.
- The findings also showed that PG leads to the release of cytochrome c into the cytosol and the cleavage of PARP, confirming that these caspases play a crucial role in PG-induced apoptosis.
Article Abstract
Prodigiosin (PG) is an active component of bacterial origin, with reported apoptotic effects. We examined the activation of caspases-9, -8, and -3 in PG-treated Jurkat cells in a dose-response study. These caspases were activated in apoptotic cells, as judged by the appearance of cleavage products from procaspases, and cytochrome c (cyt c) was released to the cytosol. In addition, PG induced the cleavage of poly (ADP-ribose) polymerase (PARP). This study demonstrates that the activation of caspases-9, -8, and -3 mediates PG-induced apoptosis.
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| http://dx.doi.org/10.1111/j.1749-6632.2002.tb04642.x | DOI Listing |
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