Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis.
J Enzyme Inhib Med Chem
December 2025
Department of Organic Chemistry, Medical University of Lublin, Lublin, Poland.
The ever-increasing drug-resistant tuberculosis (TB) has invigorated the focus on the discovery and development of novel therapeutic agents and treatment options. Thiazolidinone-based compounds have shown good antitubercular properties . Here, we report the design and synthesis of a number of new derivatives inspired by the structure of thiazolidine-2,4-dione (TZD).
View Article and Find Full Text PDFRevolutionary drug repositioning: the preventive and therapeutic potential of metformin and other antidiabetic drugs in age-related macular degeneration.
Front Pharmacol
December 2024
Kunshan Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, China.
Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly worldwide. Anti-vascular endothelial growth factor (anti-VEGF) injections remain the first-line therapy for AMD. However, their high cost and the need for frequent administration pose challenges to long-term adherence, highlighting the need for accessible and cost-effective preventive strategies.
View Article and Find Full Text PDFEffective Strategies for the Prevention and Mitigation of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia: Optimizing Patient Care.
Clin Breast Cancer
January 2025
International Diabetes Center, HealthPartners Institute, Minneapolis, MN.
Article Synopsis
- * Effective strategies before and during treatment include identifying high-risk patients, optimizing blood glucose levels, and recommending lifestyle changes such as a low-carb diet and regular exercise.
- * If hyperglycemia occurs, metformin is the first-line treatment, with other medications as alternatives, and a team approach is essential for ongoing monitoring and management to help patients continue their therapy effectively.
Management of Type 2 Diabetes Mellitus With Noninsulin Pharmacotherapy.
Am Fam Physician
April 2024
University of Texas Medical Branch, Galveston, Texas.
Article Synopsis
- Type 2 diabetes is becoming more common worldwide, and treatment should focus on individual needs, balancing costs and side effects alongside glucose control.
- Metformin is typically the first choice for treatment due to its effectiveness and affordability, while other medications like sulfonylureas and thiazolidinediones also exist but may vary in side effects like weight gain and fluid retention.
- Newer drugs, like GLP-1 receptor agonists and SGLT-2 inhibitors, have benefits such as weight loss and reduced cardiovascular risks, but they may carry risks like infections and gastrointestinal issues, and access to these medications can be limited for uninsured individuals.
Patterns of initial and first-intensifying antidiabetic drug utilization among patients with type 2 diabetes mellitus in Scotland, 2010-2020: A retrospective population-based cohort study.
Diabetes Obes Metab
July 2024
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Aim: To evaluate the utilization and prescribing patterns of antidiabetic drugs (ADDs) for patients with type 2 diabetes mellitus (T2DM) at treatment initiation and first intensification.
Methods: A retrospective cohort study was performed using linked routinely collected data of patients with T2DM who received ADDs between January 2010 and December 2020 in Scotland. The prescribing patterns were quantified using frequency/percentages, absolute/relative change, and trend tests.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!