We performed radiofrequency ablation (RFA) for 14 patients with hepatocellular carcinoma (HCC) between May 2001 and March 2002. The underlying hepatic disease was type C liver cirrhosis in all patients. Seven patients had a solitary lesion, and 7 patients had multiple lesions. RFA was chosen for the primary tumor in 5 cases and for a recurrent tumor in 9 cases. Three cases of well differentiated HCC were included. Transcatheter arterial embolization (TAE) was performed in 10 cases simultaneously. Nine patients received RFA under general anesthesia (open laparotomy: 5 cases, transthoracic: 1 case, CT guided: 2 cases, US guided: 1 case) and 5 patients under local anesthesia (CT guided: 2 cases, US guided: 3 cases). RFA was performed for 12 minutes in each session and the mean number of sessions per patient was 3.2. Excellent ablation was achieved in all cases according CT evaluation, and no additional therapy was needed. No recurrences have been found in any cases so far. RFA for HCC achieved excellent therapeutic effect in combination with other therapies as multimodal therapy.
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Discov Oncol
January 2025
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People's Republic of China.
Monotherapy with anti-programmed cell death protein 1 (PD-1) monoclonal antibody has been approved for the treatment of advanced non-small cell lung cancer with positive programmed cell death-ligand 1 (PD-L1) expression and oncogene wild type, which revealed survival benefit compared with chemotherapy. Nevertheless, certain patients develop rapid progression on anti-PD-1 inhibitor monotherapy. This novel pattern is called hyperprogressive disease (HPD), and the underlying mechanism and molecular characteristics still leaves not clear.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
January 2025
From the Division of Trauma and Critical Care, Department of Surgery (K.S.A.), Feinberg School of Medicine, Northwestern University, Illinois; Department of Surgery (K.S.A.), School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin; Department of Organ Surgery and Transplantation (M.A.C.) and Department of Organ Surgery and Transplantation (A.B.), University of Copenhagen, Copenhagen, Denmark; Department of Surgery (W.-Q.W.), Vanderbilt University Medical Center, Tennessee, Nashville; Department of Surgery (A.K.), Columbia University Medical Center, New York; Center for Genetic Medicine (J.P., M.R.-P.), Feinberg School of Medicine, Northwestern University; Department of Anesthesiology (R.J.M.), Rush University Medical Center; Division of Trauma and Critical Care, Department of Surgery (H.B.A.), Feinberg School of Medicine, Northwestern University, Chicago, IL; and Department of Organ Surgery and Transplantation (M.H.S.), University of Copenhagen, Copenhagen, Denmark.
Background: Early and accurate diagnosis of sepsis and the ensuing organ dysfunction remain a challenge in the postoperative setting. Susceptibility to infections, as well as the subsequent immunological response, are driven to some extent by the genetic predisposition of the patient. The purpose of this study was to identify novel genetic variants associated with postoperative sepsis (POS) and surgical site infections (SSIs).
View Article and Find Full Text PDFSurg Innov
January 2025
Department of Breast Surgery, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.
Background: Although there is evidence that indocyanine green angiography (ICGA) can predict mastectomy skin flap necrosis during breast reconstruction, consensus on optimal protocol is lacking. This study aimed to evaluate various technical factors which can influence ICG fluorescence intensity and thus interpretation of angiograms.
Method: Single institution retrospective study (2015-2021) of immediate implant-based breast reconstructions postmastectomy using a standardized technique of ICGA, controlling for modifiable factors of ambient lighting, camera distance and ICG dose.
J Cosmet Dermatol
January 2025
Made-Young Plastic Surgery Clinic, Seoul, Korea.
Background: Thread lifting is a minimally invasive technique for addressing facial aging and skin laxity. Despite its popularity, it carries risks of complications ranging from minor bruising to severe structural injuries. Comprehensive understanding of these complications is vital for optimizing outcomes.
View Article and Find Full Text PDFInt J Eat Disord
January 2025
University of Wisconsin-Madison, University of Texas at Austin, Madison, Wisconsin, USA.
Objective: While weight restoration and/or stabilization is crucial for successful treatment and sustained recovery from restrictive eating disorders (EDs), it is often challenging to define an individual's expected healthy body weight. This paper introduces the TeenGrowth package and its web-based application, designed to calculate and forecast predicted body mass index (BMI) and weight across adolescence.
Method: TeenGrowth includes functions for data cleaning, predicted BMI z-score and BMI calculations, and growth forecasting.
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