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The Unveiling of Therapeutic Targets for Alzheimer's Disease: An Integrative Review.
Curr Top Med Chem
June 2024
Department of Pharmaceutical Chemistry, Modern College of Pharmacy, Savitribai Phule Pune University, Pune, India.
Alzheimer's disease (AD) is characterized by a complex pathological landscape, necessitating a comprehensive treatment approach. This concise review paper delves into the idea of addressing multiple mechanisms in AD, summarizing the latest research findings on pathogenesis, risk factors, diagnostics, and therapeutic strategies. The etiology of AD is multifaceted, involving genetic, environmental, and lifestyle factors.
View Article and Find Full Text PDFAnticeramide antibody and butyrylcholinesterase in peripheral neuropathies.
J Clin Neurosci
August 2017
Nireekshana-ACET/CODEWEL, Hyderabad, Telangana 500029, India. Electronic address:
Ceramide is a glycosphingolipid, a component of nerve and non neuronal cell membrane and plays a role in maintaining the integrity of neuronal tissue. Butyrylcholinesterase (BChE) is a multifunctional enzyme, its involvement in neurodegenerative diseases has been well established. Anticeramide antibody (Ab-Cer) and enzyme BChE have been implicated in peripheral neuropathies.
View Article and Find Full Text PDFCholinesterase in leprosy nerves: a preliminary report.
Int J Lepr Other Mycobact Dis
September 2002
The clinical material included 255 cases of leprosy consisting of Tuberculoid leprosy (74), Lepromatous leprosy (116), Lepromatous leprosy with lepra reaction. Liver biopsy could be performed on 50 cases of Lepromatous leprosy. Specific granulomatous changes and parenchymal cell damage were the significant findings.
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