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Article Synopsis
  • - Duodenal-type follicular lymphoma is a rare variant of follicular lymphoma that generally has a good prognosis and can be asymptomatic or present with vague gastrointestinal symptoms.
  • - Diagnosis often happens incidentally during an endoscopic procedure (EGD) when biopsies of duodenal polyps are taken.
  • - A unique case of biopsy-confirmed duodenal-type B cell follicular lymphoma was treated with localized radiotherapy, resulting in complete remission after six months; physicians need to be aware of this rare condition and the possibility of systemic B-cell lymphoma involvement.
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Introduction: Patients with familial adenomatous polyposis (FAP) are characterised by the appearance of colorectal cancer if the disease is left to follow its natural course, which means they frequently undergo prophylactic colectomy at a young age. In these patients, duodenal cancer becomes the leading cause of death, which deems surveillance necessary. Gastric cancer, although rare, can also occur in these patients, and total gastrectomy is the usual treatment option.

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Description: Nonampullary duodenal polyps are found in up to 5% of all upper endoscopies; the vast majority are identified incidentally in asymptomatic patients. Although most are benign, adenomas are estimated to account for 10%-20% of these lesions. Most international guidelines recommend that all duodenal adenomas should be considered for endoscopic resection; this may be associated with a near 15% adverse event rate (predominantly bleeding and perforation) in prospective studies, with substantial local recurrence on surveillance.

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Background And Aims: Local recurrence is a significant concern in endoscopic resection of superficial nonampullary duodenal tumors (SNADTs). Our objective was to elucidate the clinical outcomes of salvage endoscopic treatment.

Methods: This retrospective study included consecutive patients who underwent endoscopic resection of SNADTs between January 2013 and December 2021.

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