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Automatic Single-Cell Harvesting for Fetal Nucleated Red Blood Cell Isolation on a Self-Assemble Cell Array (SACA) Chip.
Micromachines (Basel)
December 2024
Department of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
(1) Background: Fetal chromosomal examination is a critical component of modern prenatal testing. Traditionally, maternal serum biomarkers such as free β-human chorionic gonadotropin (Free β-HCG) and pregnancy-associated plasma protein A (PAPPA) have been employed for screening, achieving a detection rate of approximately 90% for fetuses with Down syndrome, albeit with a false positive rate of 5%. While amniocentesis remains the gold standard for the prenatal diagnosis of chromosomal abnormalities, including Down syndrome and Edwards syndrome, its invasive nature carries a significant risk of complications, such as infection, preterm labor, or miscarriage, occurring at a rate of 7 per 1000 procedures.
View Article and Find Full Text PDFEarly prediction of gestational diabetes mellitus using first trimester maternal serum pregnancy-associated plasma protein-a: A cross-sectional study.
Health Sci Rep
October 2024
Department of Midwifery and Reproductive Health, School of Nursing and Midwifery Shahid Beheshti University of Medical Sciences Tehran Iran.
Article Synopsis
- The study investigates the effectiveness of pregnancy-associated plasma protein-A (PAPP-A) in predicting gestational diabetes mellitus (GDM) during the first trimester of pregnancy, as current testing methods may be delayed.
- By analyzing serum PAPP-A levels in 344 pregnant women using a Bayesian statistical model, researchers sought to evaluate PAPP-A's diagnostic accuracy without relying on the gold standard glucose tolerance test.
- Results indicated that PAPP-A showed high sensitivity (92%) and specificity (81%) for detecting GDM, suggesting it could be a valuable early screening tool for this condition.
Gene deletion of Pregnancy-associated Plasma Protein-A (PAPP-A) improves pathology and cognition in an Alzheimer's disease mouse model.
Exp Neurol
December 2024
Department of Endocrinology, Mayo Clinic, Rochester, MN 55905, United States of America. Electronic address:
Article Synopsis
- Alzheimer's disease (AD) is a worsening brain condition without effective treatments, linked to the buildup of toxic β-amyloid peptides and amyloid plaques.
- Previous studies have connected the insulin-like growth factor (IGF) system to AD, and reduced IGF-I receptor (IGFIR) signaling can alleviate plaque formation and neurodegeneration in mice.
- Research highlighted that deleting PAPP-A, a protein involved in regulating IGF-I, in a mouse model of AD resulted in less plaque, improved brain function, and suggests that targeting PAPP-A could be a new treatment option for AD.
Identification of Putative Biomarkers in Cerebral Palsy: A Meta-Analysis and Meta-Regression.
Pediatr Neurol
December 2024
Neuro Medical-Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, Florida; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. Electronic address:
Background: Cerebral palsy (CP) is a neurological disorder that impairs motor abilities. Identifying maternal biomarker derangements can facilitate further evaluation for early diagnosis, potentially leading to improved clinical outcomes. This study investigates the association between maternal biomarker derangements and CP development during the antenatal period.
View Article and Find Full Text PDFPAPP-A as a Potential Target in Thyroid Eye Disease.
J Clin Endocrinol Metab
November 2024
Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Context: Proptosis in thyroid eye disease (TED) can result in facial disfigurement and visual dysfunction. Treatment with insulin-like growth factor I receptor (IGF-IR) inhibitors has been shown to be effective in reducing proptosis but with side effects.
Objective: To test the hypothesis that inhibition of IGF-IR indirectly and more selectively with PAPP-A inhibitors attenuates IGF-IR signaling in TED.
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