Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-4615-1173-1_3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Houseflies (Musca domestica) as vectors of multidrug-resistant, ESBL-producing Escherichia coli in broiler poultry farms of North India: implications for antibiotic resistance transmission.
Environ Sci Pollut Res Int
January 2025
Gut Biology Laboratory, Room No. 117, Department of Zoology, University of Delhi, New Delhi, 110007, India.
The transmission of antibiotic resistance (AR) from farm animals to healthy human communities, beyond the food chain, is often facilitated by biological vectors, notably houseflies (Musca domestica). This study aimed to evaluate the role of M. domestica collected from commercial broiler chicken farms as a carrier of multidrug-resistant (MDR), extended-spectrum β-lactamase (ESBL)-producing Escherichia coli.
View Article and Find Full Text PDFTargeting breast cancer resistance protein (BCRP/ABCG2) in cancer.
Transl Cancer Res
November 2024
Department of Pathology, Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Breast cancer is one of the most common cancers among women. Nowadays postoperative adjuvant chemotherapy is the mainstay for clinical treatment of breast cancer. However, the emergence of multidrug resistance (MDR) in breast cancer has become a main reason for the failure of clinical chemotherapy.
View Article and Find Full Text PDFHypertensive Nephropathy Changes the Expression of Drug-Metabolizing Enzymes and Transporters in Spontaneously Hypertensive Rat Liver and Kidney.
Eur J Drug Metab Pharmacokinet
November 2024
Changsha Research and Development Center on Obstetric and Gynecologic Traditional Chinese Medicine Preparation, NHC Key Laboratory of Birth Defects Research, Prevention and Treatment, Hunan Provincial Maternal and Child Health Care Hospital, No. 53 Xiangchun Road, Kaifu District, Changsha, 410008, Hunan, China.
Background And Objectives: Hypertensive nephropathy (HN) has become one of the main causes of end-stage renal disease. Drug combination therapy is a common clinical treatment for HN. However, the impact of HN on drug-metabolizing enzymes and transporters, which may lead to drug-drug interactions (DDIs) and even trigger toxic side effects, remains unclear.
View Article and Find Full Text PDFEvaluation of Novel Diaza Cage Compounds as MRP Modulators in Cancer Cells.
Anticancer Agents Med Chem
August 2024
Institute of Pharmacy, Martin-Luther, University Halle, Wittenberg, Wolfgang, Langenbeck-Str. 4, 06120 Halle, Germany.
Aim: Novel MRP modulators are needed to combat MRP-mediated multidrug resistance (MDR) in cancer cells.
Background: Anticancer drug resistance is the main problem in cancer therapy. Causative multidrug efflux pumps are attractive target structures for the development of inhibitors of their activity.
4-{3-[(Pyridin-4-ylmethyl)amino]-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl}phenol: An improved anticancer agent in hepatocellular carcinoma and a selective MDR1/MRP modulator.
Arch Pharm (Weinheim)
June 2024
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Hepatocellular carcinoma is the most common type of primary liver cancer. However, multidrug resistance (MDR) is a major obstacle to the effective chemotherapy of cancer cells. This report documents the rational design, synthesis, and biological evaluation of a novel series of triazolotriazines substituted with CHNH-linked pyridine for use as dual c-Met/MDR inhibitors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!