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Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer's Disease.
Biomedicines
December 2022
Department of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, Croatia.
Article Synopsis
- A decrease in serotonergic transmission is an early sign of Alzheimer's disease (AD) and affects serotonin receptors, impacting behavioral and psychological symptoms in patients.
- The study analyzed 115 AD patients, 53 with mild cognitive impairment, and 2701 healthy controls to see if specific gene polymorphisms were linked to faster disease progression and AD-related pathology.
- Findings showed significant associations between certain genetic markers and changes in cerebrospinal fluid biomarkers, as well as poorer cognitive performance, suggesting these polymorphisms may play a role in AD's development and progression.
Effect of 5-HT2C receptor gene polymorphism (HTR2C-759C/T) on metabolic adverse effects in Thai psychiatric patients treated with risperidone.
Pharmacoepidemiol Drug Saf
June 2021
Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: The use of Atypical antipsychotics (AAPs) is related to metabolic disturbances, which put psychiatric patients at risk for cardiovascular morbidity and mortality. Evidence is emerging of genetic risk factors. The HTR2C gene is an essential candidate in pharmacogenetic studies of antipsychotic-induced metabolic effects.
View Article and Find Full Text PDFRisperidone-Induced Obesity in Children and Adolescents With Autism Spectrum Disorder: Genetic and Clinical Risk Factors.
Front Pharmacol
November 2020
Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Obesity is a significant problem for patients taking atypical antipsychotics. There were two aims of our study. The first aim was to compare the prevalence of overweight and obesity between children and adolescents with autism spectrum disorder (ASD) treated with risperidone with the general pediatric population.
View Article and Find Full Text PDFAssociation of the HTR2C-759C/T polymorphism and antipsychotic-induced weight gain: a meta-analysis.
Gen Psychiatr
May 2020
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health Center, Shanghai, China.
Background: Antipsychotic-induced weight gain (AIWG) is a crucial factor for the medication cessation of patients with schizophrenia. Multiple studies have shown that the functional polymorphism -759 C/T (rs3813929) in the promoter region could possibly be correlated with AIWG.
Aim: To evaluate the genetic association of the HTR2C-759C/T polymorphism and AIWG in patients with schizophrenia with antipsychotic drugs (APDs) administration.
Association of Serotonin Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia.
Front Psychiatry
February 2019
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Evanston, IL, United States.
There is conflicting evidence for the association between genetic polymorphisms in the serotonin (5-HT) receptor (HTR2C) and response to antipsychotic drugs (APD) in schizophrenic patients. We tested the association between the HTR2C polymorphisms, Cys23Ser, -759C/T, and -697G/C, and response to APDs (mainly clozapine) in a 6 month prospective study in 171 patients with schizophrenia. Ser23 was significantly associated with treatment response (positive symptoms, = 7.
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