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The Gene Variants and the Effectiveness of Platelet-Rich Plasma Treatment of Lateral Elbow Tendinopathy: A Prospective Cohort Study with a Two-Year Follow-Up.
Int J Mol Sci
December 2024
Department of Biochemistry and Medical Genetics, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medykow 18 Str., 40-752 Katowice, Poland.
Platelet-rich plasma (PRP) is an autologous preparation used to accelerate regeneration; however, this form of therapy is not always effective. Vascular endothelial growth factor B (), which affects vessel survival, pathological angiogenesis, and muscle development may differentiate the risk and treatment of lateral elbow tendinopathy (LET). In this study, we analyzed the influence of gene polymorphisms on the effectiveness of LET treatment with PRP.
View Article and Find Full Text PDFGenetic Determinants of Endurance: A Narrative Review on Elite Athlete Status and Performance.
Int J Mol Sci
December 2024
Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdańsk, Poland.
This narrative review explores the relationship between genetics and elite endurance athletes, summarizes the current literature, highlights some novel findings, and provides a physiological basis for understanding the mechanistic effects of genetics in sport. Key genetic markers include R577X (muscle fiber composition), I/D (cardiovascular efficiency), and polymorphisms in , , and , influencing energy metabolism, angiogenesis, and cardiovascular function. This review underscores the benefits of a multi-omics approach to better understand the complex interactions between genetic polymorphisms and physiological traits.
View Article and Find Full Text PDFThe MDM2 SNP309 differentially impacts cardiorespiratory fitness in young healthy women and men.
Eur J Appl Physiol
December 2024
School of Kinesiology and Health Science, Faculty of Health, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada.
Purpose: Maximal oxygen consumption (VOmax), the predominant index of cardiorespiratory fitness (CRF), is a predictor of whole-body function and longevity in humans. The central cardiac function and the skeletal muscle's capacity to use oxygen are key determinants of VOmax. Murine Double Minute 2 (MDM2), mainly known as an oncogene, could regulate myocardial hypertrophy, skeletal muscle angiogenesis, and oxidative phosphorylation.
View Article and Find Full Text PDFDysregulated Vitamin D, , , and Δ32 Gene Variations are Associated with Coronary Artery Disease.
Discov Med
November 2024
Department of Medical Lab Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, 71491 Tabuk, Saudi Arabia.
Article Synopsis
- - Insufficient vitamin D levels are linked to chronic conditions like cancers, diabetes, and cardiovascular diseases, particularly coronary artery disease (CAD), with enzymes involved in vitamin D metabolism potentially affecting these levels.
- - The study analyzed genetic mutations (rs1562902 C > T, rs12255372 G > T, and Δ32 bp deletion) for their relationships with reduced vitamin D and CAD risk, using specific PCR techniques for genotyping.
- - Results showed significant associations between certain genetic variants and higher CAD risk, particularly the rs1562902 C > T genotype and Δ32 deletion, suggesting these mutations may be genetic indicators for CAD susceptibility.
Genomic Insights into Tibetan Sheep Adaptation to Different Altitude Environments.
Int J Mol Sci
November 2024
Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
Article Synopsis
- Recent research has focused on how animals, like Tibetan sheep, adapt to low oxygen (hypoxic) conditions at various altitudes, particularly examining genetic factors.
- A study sequenced the genomes of 60 Tibetan sheep from three altitude groups (medium, high, and ultra-high) and found distinct genetic differences, with some groups exchanging genes due to geographical proximity.
- Findings indicate that ultra-high-altitude adaptation genes enhance oxygen uptake mechanisms, while high-altitude genes influence mitochondrial function and cellular processes, revealing critical insights into how these sheep survive in oxygen-scarce environments.
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