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Zebrafish: A Cost-Effective Model for Enhanced Forensic Toxicology Capabilities in Low- and Middle-Income Countries.
Cureus
December 2024
Zebrafish Research Unit, Mahatma Gandhi Medical Advanced Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be-University), Pondicherry, IND.
Low- and middle-income countries (LMICs) are increasingly challenged by the rising burden of medicolegal cases. Traditional forensic infrastructure and in vivo rodent models often have significant limitations due to high costs and ethical concerns. As a result, zebrafish () are gaining popularity as an attractive alternative model for LMICs because of their cost-effectiveness and practical advantages.
View Article and Find Full Text PDFInterlaboratory comparison of particle filtration efficiency testing equipment.
J Occup Environ Hyg
January 2025
Metrology Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
Particle filtration efficiency (PFE) is a critical property of face masks, with the most common test methods using sodium chloride as a challenge aerosol. In the absence of bottom-up uncertainty budgets for PFE, interlaboratory comparisons provide an alternative route to robustly quantify the precision and bias of the method. This work presents the results of several interlaboratory comparisons of particle filtration efficiency performed across a network of laboratories.
View Article and Find Full Text PDFAccurate evaluation of factor VIII activity of efanesoctocog alfa in the presence of emicizumab.
J Thromb Haemost
January 2025
French Reference Center for Hemophilia, Hospices Civils de Lyon, Hemostasis&Thrombosis, UR4609 Universite Claude Bernard Lyon 1, Lyon, France. Electronic address:
Background: Efanesoctocog is a B-domain-deleted, Fc-fusion factor (F)VIII linked to the D'D3 domain of von Willebrand factor and 2 XTEN polypeptides, designed for an ultra-extended half-life for prophylaxis in hemophilia A, but also aiding in managing acute bleeding or surgery in patients on long-term emicizumab. However, no current laboratory method accurately measures FVIII levels in the presence of emicizumab.
Objectives: To test whether the bovine chromogenic FVIII assay, specifically calibrated for efanesoctocog, could provide an accurate assessment of efanesoctocog activity.
A Ge.F.I. Collaborative Study: Evaluating Reproducibility and Accuracy of a DNA-Methylation-Based Age-Predictive Assay for Routine Implementation in Forensic Casework.
Electrophoresis
January 2025
Forensic Sciences Laboratory, Section of Legal Medicine, Department of Medicine and Surgery, Santa Maria Hospital, University of Perugia, Terni, Italy.
The increasing interest in DNA methylation (DNAm) analysis within the forensic scientific community prompted a collaborative project by Ge.F.I.
View Article and Find Full Text PDFInterlaboratory assays from the fungal PCR Initiative and the Modimucor Study Group to improve qPCR detection of Mucorales DNA in serum: one more step toward standardization.
J Clin Microbiol
December 2024
Chrono-environnement UMR6249, CNRS, University of Franche-Comté, Besançon, Bourgogne-Franche-Comté, France.
Article Synopsis
- The study aimed to standardize qPCR procedures for diagnosing Mucorales by examining factors that influence DNA extraction and PCR amplification efficiency.
- Two panels of samples were distributed to 26 laboratories, and results showed that using larger serum volumes for DNA extraction and larger input volumes for PCR significantly improved detection sensitivity.
- Findings highlight the importance of optimizing laboratory techniques to enhance diagnosis of Mucormycosis, a serious fungal infection, which is critical for timely treatment in vulnerable patients.
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