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Protective Effects of Allicin on Acute Myocardial Infarction in Rats Hydrogen Sulfide-mediated Regulation of Coronary Arterial Vasomotor Function and Myocardial Calcium Transport.
Front Pharmacol
January 2022
Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Acute myocardial infarction (AMI) is a condition with high morbidity and mortality, for which effective treatments are lacking. Allicin has been reported to exert therapeutic effects on AMI, but the underlying mechanisms of its action have not been fully elucidated. To investigate this, a rat model of AMI was generated by ligating the left anterior descending branch of the coronary artery.
View Article and Find Full Text PDFThe protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway.
Aging (Albany NY)
August 2021
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Purpose: To investigate the protective effect and mechanism of allicin on myocardial ischemia-reperfusion (MI/R) injury.
Methods: We investigated the mechanisms by which allicin attenuated the MI/R injury by focusing on phosphoinositide 3-kinase, G protein coupled receptor kinases 2, phospholipase Cγ and cardiomyocyte apoptosis. Sixty male mice were randomly assigned into three groups: repeated MI/R (model), sham-operated (control), and MI/R+ allicin group (allicin).
Allicin prevents the formation of Proteus-induced urinary crystals and the blockage of catheter in a bladder model in vitro.
Microb Pathog
July 2019
Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address:
Stone formation and catheter blockage are major complications of Proteus UTIs. In this study, we investigated the ability of allicin to inhibit P. mirabilis-induced struvite crystallization and catheter blockage using a synthetic bladder model.
View Article and Find Full Text PDFAllicin Inhibits Glutamate Release from Rat Cerebral Cortex Nerve Terminals Through Suppressing Ca Influx and Protein Kinase C Activity.
J Med Food
July 2019
3 School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Evidence indicates that indirect inhibitory regulation of glutamatergic transmission, via reducing glutamate release, may induce neuroprotection. The present work was designed to examine whether allicin, a major component of garlic with neuroprotective effects, affected the release of glutamate evoked by 4-aminopyridine in rat cerebrocortical nerve terminals (synaptosomes). Allicin caused a potent inhibition on the release of glutamate evoked by 4-aminopyridine, and this inhibitory effect was abolished in the presence of Ca-free medium and vesicular transporter inhibitor.
View Article and Find Full Text PDFAllicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania.
PLoS Negl Trop Dis
March 2016
Department of Animal Health, Group ICPVet, Faculty of Veterinary Medicine, University Complutense Madrid, Spain.
Background: Allicin has shown antileishmanial activity in vitro and in vivo. However the mechanism of action underlying its antiproliferative effect against Leishmania has been virtually unexplored. In this paper, we present the results obtained in L.
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