A 65-year-old man was a diagnosed with meningitis and bacteremia, as Streptococcus pneumoniae was isolated from spinal fluid and blood cultures. After three weeks of antibiotic therapy, computed tomography revealed a ruptured aneurysm of the descending thoracic aorta. The aneurysm had appeared during the first episode of meningitis but had remained silent for two years. The patient underwent in situ Dacron graft replacement and his postoperative course was uneventful with no infectious complication.
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Fracture properties of porcine versus human thoracic aortas from tricuspid/bicuspid aortic valve patients via symmetry-constraint Compact Tension testing.
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Department of Engineering Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden.
Aneurysm rupture is a life-threatening event, yet its underlying mechanisms remain largely unclear. This study investigated the fracture properties of the thoracic aneurysmatic aorta (TAA) using the symmetry-constraint Compact Tension (symconCT) test and compared results to native and enzymatic-treated porcine aortas' tests. With age, the aortic stiffness increased, and tissues ruptured at lower fracture energy [Formula: see text].
View Article and Find Full Text PDFSexual dimorphism in pathogenic variant-harbouring individuals.
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Background: Individuals harbouring pathogenic variants are at risk for aneurysms/dissections throughout the arterial tree. Based on prior reports of sex differences in thoracic aortic aneurysm/dissection, we investigated the sexual dimorphism for vascular events in variant-harbouring patients.
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Embolized Transcatheter Aortic Valve Replacement Diagnosed With Transesophageal Echocardiography and a Novel Management Strategy Using a Thoracic Endovascular Aneurysm Repair Stent.
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Article Synopsis
- The study investigates the differences between smooth muscle cells (SMCs) from two lineages in the proximal thoracic aorta, specifically the second heart field (SHF) and cardiac neural crest.
- Researchers used advanced techniques like single-cell RNA sequencing and chromatin accessibility assays to analyze these cells in male mice, identifying distinct gene expressions in both lineages.
- Findings reveal that SHF-derived SMCs have unique transcriptomic profiles that may influence their functions in thoracic aortic diseases, suggesting lineage-specific roles in vascular health.
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