Objective: To evaluate the preoperative antibiotic prophylaxis (PAP) prescriptions in a surgical site infection (SSI) surveillance network.
Study Design: Auto-evaluative audit in a prospective multicenter cohort included in a surveillance system.
Patients And Methods: Since 1997, surgical wards in volunteer centers monitored all surgery patients each year during a period of two months. Patients were evaluated for SSI during the 30 days following surgery. Participating centers were asked in 2000 to participate to a PAP practice assessment. For each surgery patient, a questionnaire was completed. The "Guidelines for Antibiotic Prophylaxis Prescription in Surgery" edited in 1999 by the Société française d'anesthésie et de réanimation was used as gold standard.
Results: 6109 patients were included in the survey from 34 health care centers and 3881 received PAP. 90% of patients received PAP intravenously and 63% received twice the curative dose. PAP was administered within 90 minutes prior to incision in 70% of cases. 78% of PAP lasted less than 24 hours. PAP indication with regards to the type of surgical procedures was assessed in 4629 patients. PAP guidelines were observed in 1573 (34%) patients: 999 patients in whom PAP was not indicated did not receive PAP and 574 received it in compliance with recommended dose and indications.
Conclusion: Efforts should be made to improve PAP prescription according to standards guidelines.
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http://dx.doi.org/10.1016/s0750-7658(02)00705-0 | DOI Listing |
J Clin Med
January 2025
Department of General, Visceral and Transplantation Surgery, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, Germany.
: A positive intraoperative bile culture (bacterobilia) is considered to be a risk factor for increased morbidity after pancreatoduodenectomy. The aim of our study was to describe the frequency of bacterobilia with a special emphasis on antibiotic resistance and to analyze the association of these findings with postoperative complications, in particular with postoperative pancreatic fistula. : From a prospective database, patients with available intraoperative bile cultures (n = 95) were selected and analyzed.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Orthopaedic Surgery, UPMC Freddie Fu Sports Medicine Center, University of Pittsburgh Medical Center, 3200 S Water St., Pittsburgh, PA 15203, USA.
: Postoperative infection following anterior cruciate ligament reconstruction (ACLR) is a rare yet severe complication that can compromise patient outcomes, leading to prolonged recovery, graft failure, and knee dysfunction. Although infection rates are reported to be less than 2%, it remains essential to implement strategies to reduce infection risk and improve surgical outcomes. : This review explores current evidence on the prevention of infections in ACLR, emphasizing the importance of timely antibiotic prophylaxis and vancomycin presoaking of grafts, which has been associated with a substantial reduction in infection rates.
View Article and Find Full Text PDFBiomolecules
January 2025
Cancer Research Center, Semnan University of Medical Sciences, Semnan 35147-99442, Iran.
The growing prevalence of antibiotic-resistant bacteria within the human microbiome has become a pressing global health crisis. While antibiotics have revolutionized medicine by significantly reducing mortality and enabling advanced medical interventions, their misuse and overuse have led to the emergence of resistant bacterial strains. Key resistance mechanisms include genetic mutations, horizontal gene transfer, and biofilm formation, with the human microbiota acting as a reservoir for antibiotic resistance genes (ARGs).
View Article and Find Full Text PDFAntibiotics (Basel)
January 2025
Department of Prosthodontics, Study of Dental Medicine, University of Split School of Medicine, 21000 Split, Croatia.
: This study aimed to explore antibiotic prescribing practices for dental implant placement in Croatia. : We conducted a cross-sectional questionnaire-based study including dentists in Croatia who perform dental implant therapy. The questionnaire assessed the dentists' age, working experience, education level, and whether they use antibiotics for dental implant placement, as well as the choice of antibiotics, timing, and reasons for antibiotics use.
View Article and Find Full Text PDFAntibiotics (Basel)
January 2025
Institute for Hygiene and Public Health, Medical Faculty, University of Bonn, Haus 33, 53113 Bonn, Germany.
Background/objectives: Antimicrobial resistance is a global threat to safe health care, and a reduction in antibiotic consumption seems to be an appropriate preventive measure. In Germany, the reporting of hospital antibiotics consumption to an independent institution is only voluntary. Although a high level of willingness to improve can be assumed in the case of participation, the median consumptions of reporting hospitals change only slightly.
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