AI Article Synopsis
- The study aimed to explore the connection between multifocal visual evoked potentials (mfVEPs) and Humphrey visual fields (HVFs) in patients with one-sided visual field defects.
- Data was collected from 20 patients with unilateral field losses using both mfVEPs and HVFs, revealing that mfVEP amplitude decreased with HVF loss but was not linked specifically to poor visual fields.
- The findings suggest a linear relationship between mfVEP responses and HVF loss, implying that both measures may reflect the extent of local retinal ganglion cell damage.
Article Abstract
Objective: To determine the relationship between spatially localized multifocal visual evoked potentials (mfVEPs) and Humphrey visual fields (HVFs) in patients with unilateral field defects.
Methods: Humphrey visual fields and mfVEPs were obtained from 20 patients with unilateral field losses due to either ischemic optic neuropathy or glaucoma. Monocular mfVEPs were obtained for each eye. The amplitude of the mfVEP responses was calculated using root-mean-square and signal-noise ratio measures. Estimates of the HVF loss in the same regions of the field used for the mfVEP were obtained by interpolating the 24-2 HVF data.
Results: Monocular mfVEP amplitude decreased with HVF loss, although small mfVEP signals were not uniquely associated with poor fields. On average, the monocular mfVEP was indistinguishable from noise for field losses between -5 and -10 dB, and good monocular mfVEP amplitudes were never associated with extensive visual field loss. The interocular ratio of the mfVEP amplitudes correlated well with the difference between the HVF values of the 2 eyes, and this correlation improved with increased signal-noise ratio.
Conclusions: The monocular and interocular results were consistent with a linear relationship between the amplitude of the signal portion of the mfVEP response and linear HVF loss. One way to produce this relationship would be if both the signal in the mfVEP and linear HVF loss were linearly related to the percentage of local ganglion cells lost. The clinical limitations of the mfVEP technique can be understood by taking the signal-noise ratio, and the linear model proposed herein, into consideration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archopht.120.12.1672 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hydroxychloroquine retinopathy in a 23-year-old male.
Retin Cases Brief Rep
December 2024
Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Purpose: To report a case of hydroxychloroquine (HCQ) retinopathy after long-term exposure in a 23-year-old male.
Methods: Multimodal imaging including fundus photography, fundus autofluorescence (FAF), spectral domain optical coherence tomography (SD-OCT), and en face OCT were performed, in addition to functional testing with full-field electroretinography (ERG) and Humphrey visual field (HVF).
Results: A 23-year-old man with a history of juvenile systemic lupus erythematosus and HCQ treatment for 13 years at a dosage of 200 mg/d (cumulative dose: 949 grams) presented to the retinal clinic (DS).
Factors associated with vision loss in idiopathic intracranial hypertension patients with severe papilledema.
Eye (Lond)
October 2024
Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.
Background/objectives: Our aim was to compare factors associated with poor versus good visual outcomes in idiopathic intracranial hypertension (IIH) patients with severe papilledema at initial presentation.
Subjects/methods: Retrospective review of consecutive IIH patients (1/1/2013-6/10/2023) with severe papilledema (Frisén grade 4-5 and/or atrophy in at least one eye); Patients were divided into "poor visual outcome" (poor visual acuity and constricted visual field in at least one eye) and "good visual outcome" (good visual acuity and only mild visual field changes in both eyes) at >6 months for medically-treated patients and >3 months follow-up for surgically-treated patients.
Results: We included 134 IIH patients with severe papilledema (70 had poor and 64 had good visual outcomes).
Development and evaluation of Order of Magnitude (OM): a virtual reality-based visual field analyzer for glaucoma detection.
Int Ophthalmol
April 2024
VST Centre for Glaucoma Care, L V Prasad Eye Institute, Dr. Kallam Anji Reddy Campus, L V Prasad Marg, Banjara Hills, Hyderabad, Andhra Pradesh, 500 034, India.
Purpose: This study introduces the Order of Magnitude (OM), a cost-effective, indigenous, virtual reality-based visual field analyzer designed for detecting glaucomatous visual field loss.
Methods: The OM test employs a two-step supra-thresholding algorithm utilizing stimuli of 0.43°diameter (equivalent to Goldmann size III) at low and high thresholds.
Performance of virtual reality game-based automated perimetry in patients with childhood glaucoma.
J AAPOS
December 2023
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina. Electronic address:
Purpose: To evaluate VisuALL, a game-based automated perimetry device, utilizing virtual reality (VR) goggles, in a cohort of patients with childhood glaucoma.
Methods: In this prospective series, the results of consecutive patients with childhood glaucoma performing both VisuALL VR field (VRF) and Humphrey visual field (HVF) 24-2 testing were compared. A masked ophthalmologist graded both VRF and HVF tests for field defects (three clustered abnormal points in total or pattern deviation plot).
Evolution of Autoimmune Retinopathy in Stiff Person Syndrome: A Case Report.
Retin Cases Brief Rep
April 2024
Department of Ophthalmology, Duke University, Durham, NC 27710.
Purpose: To report a case of autoimmune retinopathy (AIR) as the presenting feature of Stiff Person Syndrome (SPS) and assess its evolution.
Observations: A 35-year-old man presented with progressive, chronic, vision loss. On initial examination, visual acuity measured 20/20 OD and 20/50 OS.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!