[Clinico-immunologic subtypes of type I diabetes mellitus].

Aim: To study clinico-immunological characteristics of diabetes mellitus type I.

Material And Methods: Clinical examination was made of 333 patients with diabetes mellitus type I with manifestation of carbohydrate metabolism impairment and intoxication syndrome because of diabetic ketoacidosis (group 1) and without it (group 2). Compared to donors (n = 68), T-cell, B-cell and monocytic components of immune system were studied in patients with uncomplicated DM type 1 in both groups (28 and 15 patients, respectively).

Results: Patients with different subtypes of the disease differ by the course and rate of progression, defects in T-cell and monocyte components of immunity.

Conclusion: Type 1 diabetes mellitus is a heterogenous pathology with subtype 1 (rapidly progressive) and subtype 2 (slowly progressive).