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The use of polycondensed hemoglobin as the basis of a blood substitute capable of transporting oxygen.
Dokl Biochem Biophys
May 2003
Institute of Macromolecular Compounds, Russian Academy of Sciences, Russian Institute of Hematology and Transfusion, St. Petersburg, Russia.
Synthesis of water-soluble, nonimmunogenic polyamide cross-linking agents.
Bioconjug Chem
January 1999
Hemoglobin Therapeutics Division, Baxter Healthcare Corp., 25212 West State Route 120, Round Lake, Illinois 60073, USA.
Novel polyamides were developed that can be used as cross-linking agents for proteins such as hemoglobin. Water-soluble, nonimmunogenic polyamides containing oxygen and sulfur atoms in the backbone were prepared by the polycondensation of the diacids bis(carboxymethyloxyacetyl)-1,4-diaminobutane (1a) or 3, 3'-thiodipropionic acid (1b) with diethylene glycol bis(3-aminopropyl) ether (2). The resulting alpha,omega-diacids were converted to the corresponding activated esters using any of a variety of carboxylic acid activating reagents including the novel reagent diphenyl(1-methylimidazol-2-thiyl)phosphonate (9).
View Article and Find Full Text PDFSynthesis, physico-chemical and biological properties of crosslinked modified hemoglobin.
Artif Cells Blood Substit Immobil Biotechnol
March 1998
Institute of Macromolecular Compounds of Russian Academy of Sciences, St. Petersburg, Russia.
Polymer aspects of polycondensation of pyridoxylated hemoglobin with glutaraldehyde have been considered. On the basis of the investigation of reaction kinetics, the mechanism of chemical crosslinking of hemoglobin molecules into oligohemoglobin is proposed. Owing to the statistical character of the reaction, the resulting macromolecules are polydisperse with respect to the degree of modification of hemoglobin amino groups, and size of oligohemoglobin molecules.
View Article and Find Full Text PDFPolycondensation of human hemoglobin with glutaraldehyde premodified with reagents bearing acid groups (glutamic acid or sodium bisulfite), has been carried out. The resulting modified hemoglobin displays better oxygen transport characteristics in comparison with native hemoglobin.
View Article and Find Full Text PDFSolutions of oligohemoglobins (OHb) with middle molecular mass 100 x 10(3) = 400 x 10(3), obtained after polycondensation of hemoglobin with glutaric aldehyde as well as oligohemoglobin modified with pyridoxal-5-phosphate, were studied in vivo and in vitro (plethoric administration, isovolemic metabolic substitution, hemorrhagic shock; at a dose of 0.5-1.8 g/kg of body mass; dogs, rabbits, rats).
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