AI Article Synopsis
- Biological polymers like proteins, membranes, and micelles have unfilled spaces called voids, which influence their behavior and properties.
- In a study of phospholipid membranes, simulations revealed that these voids are mainly caused by the shape differences in mixtures of interacting disks.
- The findings help explain the unexpected high permeability in certain liposomes, highlighting the broader significance of voids in various biological polymers.
Article Abstract
Biological polymers, viz., proteins, membranes and micelles exhibit structural discontinuities in terms of spaces unfilled by the polymeric phase, termed voids. These voids exhibit dynamics and lead to interesting properties which are experimentally demonstrable. In the specific case of phospholipid membranes, numerical simulations on a two-dimensional model system showed that voids are induced primarily due to the shape anisotropy in binary mixtures of interacting disks. The results offer a minimal description required to explain the unusually large permeation seen in liposomes made up of specific lipid mixtures (Mathai & Sitaramam, 1994). The results are of wider interest, voids being ubiquitous in biopolymers.
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| http://dx.doi.org/10.1006/jtbi.2003.3155 | DOI Listing |
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