Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives.

Bioorg Med Chem Lett

UPRES A 8076 BioCIS, Laboratoire de synthèse et conception des molécules d'intérêt thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay Malabry Cedex, France.

Published: January 2003

2-Methoxyprop-2-yl peroxides were synthesized and evaluated in vitro against Plasmodium falciparum. These acyclic artemisinin-related peroxides revealed moderate to good activity but were devoid of alkylating property towards the synthetic model of heme Mn(II)-TPP.

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http://dx.doi.org/10.1016/s0960-894x(02)00837-5DOI Listing

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