In 1958 a virus transmitted by a mosquito was isolated in the Slovakian village of Tahyna. Since this virus was unknown in Europe, a detailed study was begun. It was shown that this virus belonged to the California group of arboviruses and occurs in practically all European countries. It could very well be that young hares are the hosts for this virus, and that it multiplies in them. Foals and suckling pigs are also hosts and possibly also increase the virus. In patients observed so far, infection with the Tahyna virus appears with influenza-like symptoms. In some cases, meningoencephalitis and atypical pneumonia were observed.
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Viruses
December 2024
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, CA 92093-0657, USA.
Dengue, West Nile, Zika, Yellow fever, and Japanese encephalitis viruses persist as significant global health threats. The development of new therapeutic strategies based on inhibiting essential viral enzymes or viral-host protein interactions is problematic due to the fast mutation rate and rapid emergence of drug resistance. This study focuses on the NS2B-NS3 protease as a promising target for antiviral drug development.
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January 2025
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, Maryland, United States of America.
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February 2025
Department of Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, USA.
Engineered monoclonal antibodies have proven to be highly effective therapeutics in recent viral outbreaks. However, despite technical advancements, an ability to rapidly adapt or increase antibody affinity and by extension, therapeutic efficacy, has yet to be fully realized. We endeavored to stand-up such a pipeline using molecular modeling combined with experimental library screening to increase the affinity of F5, a monoclonal antibody with potent neutralizing activity against Venezuelan Equine Encephalitis Virus (VEEV), to recombinant VEEV (IAB) E1E2 antigen.
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December 2024
Public Health Agency of Canada (PHAC), Winnipeg, MB, Canada.
The California serogroup (CSG) viruses are orthobunyaviruses endemic in North America and responsible for the second most common cause of mosquito-borne viral encephalitis in the United States. As the CSG viruses have been neglected and are poorly studied, there are no commercial diagnostic serological assays or reagents available for detection. Therefore, diagnostic laboratories have had to rely on the development of their own in-house serological assays.
View Article and Find Full Text PDFViruses
October 2024
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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