The title compound, Na(+).C(5)H(9)N(2)O(7)P(2)(-).4H(2)O, is an isomer of zoledronate, a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. The crystal structure of isozoledronate consists of bisphosphonate dimers coordinated by two Na(+) ions. The dimers are held together through an extensive hydrogen-bonding network. The crystals exhibit non-merohedral twinning that roughly superimposes the a and b axes, and inverts the c axis.
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