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KGF impedes TRIM21-enhanced stabilization of keratin 10 mediating differentiation in hypopharyngeal cancer.
Cell Signal
January 2025
Key Laboratory, Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao University, 266003 Qingdao, China. Electronic address:
KGF, also known as FGF7, is a member of the fibroblast growth factor (FGF) family that binds with high affinity to the FGF receptor 2b (FGFR2b) and regulates various cellular processes, including cell proliferation and differentiation in a variety of tumors. However, its potential role in hypopharyngeal cancer (HPC) remains largely unknown. In our study, we observed increased expression of FGFR2b in HPC.
View Article and Find Full Text PDFVibro-tactile stimulation of the neck induces head righting in people with cervical dystonia.
Parkinsonism Relat Disord
January 2025
Human Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, USA; Center for Clinical Movement Science, University of Minnesota, USA.
Introduction: Cervical dystonia (CD) is characterized by involuntary neck muscle spasms that lead to abnormal head movements or postures. It is associated with somatosensory (tactile and proprioceptive) dysfunction. Here we tested whether vibro-tactile stimulation (VTS) of the cervical muscles constitutes a non-invasive form of neuromodulation of the somatosensory system that can provide temporary symptom relief for people with CD.
View Article and Find Full Text PDFUse of Intraoperative Frozen Section to Assess Surgical Margins in HPV-Related Oropharyngeal Carcinoma.
JAMA Otolaryngol Head Neck Surg
January 2025
Department of Otolaryngology/Head and Neck Surgery, Washington University in St Louis School of Medicine, St Louis, Missouri.
Importance: Given the favorable overall prognosis of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and the morbidity of increased adjuvant therapy associated with positive surgical margins, large-scale studies on the accuracy of frozen sections in predicting final surgical margin status in HPV-related OPSCC are imperative. Final surgical margin status is the definitive assessment of tumor clearance as determined through surgeon-pathologist collaboration based on permanent analysis of frozen section margins, main specimens, and supplemental resections.
Objectives: To assess the accuracy and testing properties of intraoperative frozen section histology (IFSH) in assessing final surgical margin status in patients undergoing transoral surgery for HPV-related OPSCC.
Biological, linguistic, and individual factors govern voice qualitya).
J Acoust Soc Am
January 2025
USC Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-1455, USA.
Voice quality serves as a rich source of information about speakers, providing listeners with impressions of identity, emotional state, age, sex, reproductive fitness, and other biologically and socially salient characteristics. Understanding how this information is transmitted, accessed, and exploited requires knowledge of the psychoacoustic dimensions along which voices vary, an area that remains largely unexplored. Recent studies of English speakers have shown that two factors related to speaker size and arousal consistently emerge as the most important determinants of quality, regardless of who is speaking.
View Article and Find Full Text PDFScala tympani drill-out technique for oval window atresia with malformed facial nerve:update.
Acta Otolaryngol
January 2025
Department of Otomicrosurgery, Sixth Medical Center of The PLA General Hospital, Beijing, China.
Background: In some rare cases of congenital aplasia of the oval window (OW), malformed facial nerve (FN) locations covering the most or entire OW present a challenge to hearing reconstruction, there is no a highly effective surgical hearing reconstruction methods.
Aims/objectives: To update a Scala tympani drill-out technique (SDT) for abnormal FN course covering the OW.
Material And Methods: All patients of congenital atresia of the OW was recruited between August 2014 and July 2023 in a tertiary-care center.
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