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Expanding the landscape of systemic sclerosis-related autoantibodies through RNA immunoprecipitation coupled with massive parallel sequencing.
J Autoimmun
December 2024
Systemic Autoimmune Diseases Unit, Internal Medicine Department, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Systemic Autoimmune Diseases Group, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Article Synopsis
- The study focused on creating a new test to detect specific autoantibodies in patients with systemic sclerosis (SSc) using RNA immunoprecipitation and massive parallel sequencing techniques.
- Researchers analyzed serum samples from 307 SSc patients, with 57 undergoing detailed testing that identified 30,966 RNA molecules, ultimately narrowing down to 197 significant molecules linked to SSc-related autoantibodies.
- The new assay demonstrated high sensitivity and specificity in detecting autoantibodies, revealing not only known targets but also potential new ones associated with different clinical aspects of SSc.
The major vault protein integrates adhesion-driven signals to regulate collagen remodeling.
Cell Signal
December 2024
Faculty of Dentistry, University of Toronto, Toronto, ON, Canada. Electronic address:
Article Synopsis
- DDR1 interacts with fibrillar collagen and influences β1 integrin signaling, but the specific mechanisms are unclear.
- When DDR1 is activated by collagen, it significantly reduces β1 integrin-dependent ERK phosphorylation, impacting MMP1 expression; inhibiting DDR1 or using fibronectin reverses this effect.
- Major vault protein (MVP) is identified as a key player, linking DDR1 and focal adhesion kinase (FAK) interactions, and its knockdown restores ERK activity and MMP1 in DDR1-expressing cells, suggesting MVP's role in regulating collagen degradation signaling in invasive cancers.
Major Vault Protein/Lung Resistance-Related Protein: A Novel Biomarker for Inflammation and Acute Infections.
Microorganisms
August 2024
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Introduction: Vault particles are large cytoplasmic ribonucleoprotein particles that participate in inflammation. The aim of this study was to assess the diagnostic and prognostic value of major vault protein (MVP) in patients with inflammation, in order to determine whether MVP could be used as a biomarker for infection or inflammation. We also aimed to compare the diagnostic impact of MVP compared to other conventional measurements, such as CRP or white blood cell (WBC) counts.
View Article and Find Full Text PDFSingle-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance.
Nat Chem Biol
January 2025
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Clinical resistance to rat sarcoma virus (Ras)-G12C inhibitors is a challenge. A subpopulation of cancer cells has been shown to undergo genomic and transcriptional alterations to facilitate drug resistance but the immediate adaptive effects on Ras signaling in response to these drugs at the single-cell level is not well understood. Here, we used Ras biosensors to profile the activity and signaling environment of endogenous Ras at the single-cell level.
View Article and Find Full Text PDFMajor vault protein directly enhances adaptive immunity induced by Influenza A virus or indirectly through innate immunity.
Biochim Biophys Acta Mol Basis Dis
October 2024
State Key Laboratory of Virology, Modern Virology Research Center, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, College of Life Sciences, Wuhan University, Wuhan 430072, China; Institute of Myocardial Injury and Repair, Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430072, China; Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan 430072, China; Department of General Surgery, Ganzhou Key Laboratory of Thyroid Cancer, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, China. Electronic address:
Article Synopsis
- Major vault protein (MVP) is essential for innate immune responses, but its role in adaptive immunity was unclear until this study.
- The research found that mice without MVP (Mvp knockout) had weaker antibody responses and lower survival rates when faced with the influenza A virus again, compared to normal mice.
- MVP enhances germinal center (GC) responses for better antibody production and supports T cell activation, indicating its crucial role in developing effective immunity against influenza.
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