AI Article Synopsis
- Increased vagal tone has been linked to successful treatment of major depression through medications and cognitive-behavioral therapy, but not with electroconvulsive therapy.
- A study involving 16 subjects measured changes in vagal tone and depression levels before and after treatment using the Hamilton Rating Scale for Depression (HRSD) and ECG.
- Results showed that participants with significant increases in vagal tone had a greater reduction in depression symptoms, suggesting that vagal tone changes could be related to better treatment outcomes, prompting further exploration of its role in depression.
Article Abstract
Increased vagal tone has been associated with treatment success using pharmacological agents and cognitive-behavioral treatment in major depression, but not using electroconvulsive therapy. The present study investigated whether increases in vagal tone would be associated with favorable treatment response with nonpharmacological treatment. At baseline and following treatment, 16 subjects were administered the Hamilton Rating Scale for Depression (HRSD) followed by electrocardiographic recording. Those with little change in vagal tone from before to after treatment showed minimal reduction in HRSD score (-4.8); those with larger vagal tone change showed a large decrease in HRSD score (-14.8). Changes in vagal tone are thus related to favorable treatment response in depression, and do not represent anticholinergic pharmacological effects. Future work manipulating vagal tone might prove informative in teasing apart the causal role of vagal tone and depression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1469-8986.3960861 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!