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[Clinical characteristics and prognosis of ovarian juvenile granulosa cell tumors].
Zhonghua Fu Chan Ke Za Zhi
January 2025
Department of Gynecology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing100021, China.
To analyze the clinical characteristics, treatments, and prognosis of patients with ovarian juvenile granulosa cell tumor (JGCT). Clinical and pathological data, and follow-up information of 34 patients diagnosed with JGCT from 2000 to 2021 were collected from the surveillance, epidemiology, and end results (SEER) database. A retrospective analysis was conducted to summarize the patients' clinical and pathological characteristics, treatments, and prognosis.
View Article and Find Full Text PDFComplex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway.
Diagn Pathol
January 2025
Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studničkova 2, Prague, 12800, Czech Republic.
Background: Juvenile granulosa cell tumor (JGCT) of the ovary is a rare tumor with distinct clinicopathological and hormonal features primarily affecting young women and children. We conducted a complex clinicopathological, immunohistochemical, and molecular analysis of five cases of JGCT.
Methods: The immunohistochemical examination was performed with 32 markers, including markers that have not been previously investigated.
Is there a role of cytoreductive surgery with HIPEC in recurrent ovarian granulosa cell tumors? An Indian cancer center experience with review of literature.
Indian J Cancer
January 2024
Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- Granulosa cell tumors (GCTs) are common ovarian tumors associated with a good prognosis but a tendency for late recurrences, making treatment difficult.
- A study evaluated the effects of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) on eight patients with recurrent adult GCTs, showing a median overall survival of 11.5 months post-treatment.
- The procedure demonstrated acceptable levels of postoperative complications, but more research is needed to confirm its effectiveness as a treatment option for recurrent GCTs.
Oncologic and fertility outcomes in patients with juvenile granulosa cell tumor - a retrospective single centre analysis.
Gynecol Oncol
January 2025
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. Electronic address:
Background: Granulosa cell tumors (GCTs) are rare neoplasia that account for less than 5 % of all the ovarian tumors. Juvenile GCT histotype is generally observed in adolescent and young women, representing a very rare disease, so only a paucity of data are present in literature. The aim of this study is to analyse the oncologic and fertility outcome in our case series of juvenile GCTs.
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