Background: The S-Caine peel (Zars, Inc., Salt Lake City, UT) is a novel eutectic lidocaine/tetracaine mixture that is applied as a cream, drying upon exposure to air to form a flexible film that can be peeled off easily. The patented formulation can be used to anesthetize the skin prior to a variety of cutaneous procedures.
Objective: To examine the clinical efficacy of the S-Caine peel as a topical anesthetic for pulsed dye laser (PDL) treatment and to determine the optimal application time for adequate cutaneous anesthesia.
Methods: Sixty patients were enrolled in one of three separate double-blind, placebo-controlled protocols in which the active product or a placebo was applied to the skin and left intact for 20, 30, or 60 minutes prior to laser treatment. A 585 nm or 595 nm PDL was used to treat facial telangiectases or port-wine stains in each protocol. Patients rated the level of pain experienced during laser treatment on a visual analog scale (VAS). Independent assessments of observed discomfort and side effects were recorded.
Results: All patients experienced significant pain reduction with the S-Caine peel as their sole topical anesthetic. An application time of 20 or 30 minutes was as effective as 60 minutes in achieving anesthesia. Side effects of the peel application were limited to transient mild erythema.
Conclusion: The S-Caine peel is a rapid, safe, and effective method of topical anesthesia for cutaneous PDL treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1046/j.1524-4725.2002.02079.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Percutaneous dermal drug delivery for local pain control.
Ther Clin Risk Manag
March 2006
Department of Dermatology and Cutaneous Surgery, University of Miami Miami, FL, USA.
Topical anesthetics have evolved from a simple solution of cocaine to creams, ointments, gels, liposomal preparations, and to the latest sophisticated patches and peels. Topical anesthetics are essential for performing diagnostic, therapeutic, and cosmetic dermatology procedures. These anesthetics noninvasively deliver anesthesia in locally required areas.
View Article and Find Full Text PDFRandomized, double-blind, placebo-controlled study evaluating the lidocaine/tetracaine patch for induction of local anesthesia prior to minor dermatologic procedures in geriatric patients.
Dermatol Surg
March 2005
Department of Dermatology, Brown Medical School, Providence, Rhode Island, USA.
Background: Topical anesthetics offer a noninvasive method of anesthesia.
Objective: To evaluate the efficacy and safety of the lidocaine/tetracaine patch, a 1:1 (wt:wt) eutectic mixture of lidocaine and tetracaine, for local anesthesia before minor dermatologic procedures in geriatric patients.
Methods: In a multicenter, randomized, double-blind, placebo-controlled study, 79 patients over the age of 65 years received a 30-minute application of either the lidocaine/tetracaine patch or placebo immediately before a shave biopsy or superficial excision.
Evaluation of the S-Caine Peel for induction of local anesthesia for laser-assisted tattoo removal: randomized, double-blind, placebo-controlled, multicenter study.
Dermatol Surg
March 2005
Division of Dermatology, University of Louisville, Louisville, Kentucky, USA.
Background: Topical anesthetics are important tools for many dermatologic procedures. The S-Caine Peel is composed of a 1:1 (w:w) eutectic mixture composed of lidocaine base 7%, USP, and tetracaine base 7%, USP. It is applied as a cream, dries on exposure to air, and forms a flexible membrane, which can be easily peeled off.
View Article and Find Full Text PDFA randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children.
Anesthesiology
February 2005
Harvard Medical School, Department of Anesthesiology, Perioperative and Pain Medicine, Children's Hospital Boston, MA, USA.
Background: A randomized, double-blinded trial was performed to evaluate the efficacy and safety of the S-Caine Patch (ZARS, Inc., Salt Lake City, UT), a eutectic mixture of lidocaine and tetracaine, for pain relief during venipuncture in children.
Methods: With institutional review board approval, parental consent, and patient assent, 64 children who were scheduled for medically indicated vascular access at two centers were randomly assigned (2:1) to receive either an S-Caine Patch or a placebo patch for 20 min before venipuncture procedures.
60-minute application of S-Caine Peel prior to 1,064 nm long-pulsed Nd:YAG laser treatment of leg veins.
Lasers Surg Med
November 2004
DermSurgery Associates, Houston, Texas 77030, USA.
Background And Objectives: Advancements in laser treatment of leg veins necessitate concurrent investigations in topical anesthesia to minimize treatment-related pain. To evaluate the efficacy of the S-Caine Peel for providing topical anesthesia after a 60-minute application.
Study Design/patients And Methods: A randomized, double-blinded, placebo-controlled trial was performed in two centers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!