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Genetic overlap between inflammatory bowel disease and iridocyclitis: insights from a genome-wide association study in a European population.
BMC Genom Data
October 2024
Formula-Pattern Research Center, Jiangxi University of Chinese Medicine, Nanchang, China.
Article Synopsis
- Inflammatory bowel disease (IBD) is linked with eye conditions like iridocyclitis (IC), potentially due to shared genetics, as indicated by increasing occurrences of both conditions.
- A comprehensive analysis using genetic data revealed positive correlations between IBD, ulcerative colitis (UC), and IC, particularly on chromosomes 1 and 6, but showed weaker connections for Crohn's disease (CD) and certain types of IC.
- The study identified specific genes, such as IL23R and GPR35, common to both conditions, highlighting a shared genetic foundation that may inform future treatment and prevention strategies for IBD and IC.
Yttrium-90 (Y) brachytherapy for squamous carcinoma: Treatment of the conjunctiva, cornea, and sclera.
Am J Ophthalmol Case Rep
December 2024
Duke University Eye Center, 2351 Erwin Road, Durham, NC, 27710, USA.
Purpose: Patients with conjunctival squamous cell carcinoma that present with persisting disease or recurrence following topical chemotherapy and/or surgery especially when invading the sclera are challenging to treat. Herein, we describe the use of high-dose-rate (HDR), FDA-cleared, yttrium-90 (Y) plaque brachytherapy for such lesions.
Observation: Three cases of invasive conjunctival squamous cell carcinoma that had exhibited a poor response or recurrence following topical chemotherapy and/or surgery are described.
The Frequency of Intraocular Pressure Elevation, Incidence of Secondary Glaucoma, and Surgical Treatment With Postoperative Complications in Pediatric and Adult Patients With Uveitis.
Cureus
March 2024
Department of Ophthalmology, Division of Uvea-Behçet Unit, Medical Faculty, Erciyes University, Kayseri, TUR.
Purpose To determine the etiology and anatomic localization of uveitis, the frequency of intraocular pressure (IOP) elevation, and the type of secondary glaucoma and to assess the medical, surgical, and postoperative complications in adult and pediatric patients with acute or chronic uveitis. Methods A total of 307 eyes of 186 patients who were followed up in the Uvea-Behçet Unit of the Ophthalmology Department, Erciyes University, Turkey, were included in the study. Demographic, ocular, and systemic data were recorded; ophthalmological examinations were performed; and recurrences and complications of uveitis were identified.
View Article and Find Full Text PDFManifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review.
Oman J Ophthalmol
February 2024
World-Class Research Center, Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Coronavirus infection disease-19 (COVID-19) is a worldwide catastrophic emergency that first appeared in late 2019, in Wuhan, China. COVID-19 is a multitropism disease that first affects lung tissue. However, extrapulmonary manifestations have been suspected from the first COVID-19 cases.
View Article and Find Full Text PDFAnkylosing spondylitis: acute/subacute vs. chronic iridocyclitis - a bidirectional two-sample Mendelian randomization study.
Front Immunol
January 2024
Department of Rheumatology and Immunology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen, China.
Background: Observational studies found associations between ankylosing spondylitis (AS) and iridocyclitis (IC), but the causality remained unconfirmed.
Methods: We employed two-sample Mendelian randomization (MR) to investigate the bidirectional causal relationships between AS and IC. Single-nucleotide polymorphisms (SNPs) were chosen from the FinnGen database's genome-wide association studies (GWAS) following a rigorous evaluation of the studies' quality.
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