The aqueous methanol extract (3:1, v/v) of the seeds of Cajanus cajan was investigated for antisickling properties. The extract possessed significant antisickling activity and was found to be concentration-dependent. The kinetics of reversal of presickled erythrocyte (HbSS) cells using the extract at 0.5 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 2.0 mg/mL and 2.5 mg/mL showed first-order kinetics with rate constants of 5.833 x 10(-3) min(-1), 6.143 x 10(-3) min(-1), 5.957 x 10(-3) min(-1) 6.00 x 10(-3) min(-1) and 6.046 x 10(-3) min(-1), respectively, and with an average half-life 115.6 min. Phytochemical screening of the extract revealed the presence of free amino acids, phenolic compounds, tannins, globulins and saponins. These results show that the extract has potential use in the management of painful episodes experienced by sickle cell patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ptr.1026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Construction and Band Gap-Regulation of Ordered Macro-Microporous Single Crystals of an Amine-Linked Covalent Organic Framework.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Bioinspired Interfacial Materials Science, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China.
Heterogeneity engineering provides an effective route to manipulate the chemical and physical properties of covalent organic frameworks (COFs) but is still under development for their single-crystal form. Here, we report the strategy based on a combination of the template-assisted modulated synthesis with a one-pot crystallization-reduction method to directly construct ordered macro-microporous single crystals of an amine-linked three-dimensional (3D) COF (OM-COF-300-SR). In this strategy, the colloidal crystal-templating synthesis not only assists the formation of ordered macropores but also greatly facilitates the in situ conversion of linkages (from imine to amine) in the COF-300 single crystals.
View Article and Find Full Text PDFBackground: Apart from massive weight loss, metabolic and bariatric surgery, especially gastric bypass (Roux-en-Y gastric bypass [RYGB]), can cause nutritional deficiencies. Proton pump inhibitors (PPI), relatively often used after RYGB, are associated with reduced calcium absorption. We have studied the long-term impact of PPI upon calcium homeostasis among RYGB patients.
View Article and Find Full Text PDFDetermining the Rates of α-Tocopherol Movement in DPPC Vesicles Using Small Angle Neutron Scattering.
Biophys J
January 2025
Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada. Electronic address:
α-Tocopherol (αtoc, vitamin E) is an essential nutrient sufficiently acquired through a balanced diet. This fat-soluble vitamin is most known for its antioxidative properties, however, its fundamental mechanism of action in cellular membranes remains unknown. To this end, we use time-resolved small angle neutron scattering (TR-SANS) and a contrast matching scheme to determine intervesicular exchange (k) and intrabilayer flip-flop (k) rates of αtoc in 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) vesicles.
View Article and Find Full Text PDFInvolvement of inorganic nitrogen species (NO (x = 2, 3)) in the degradation of organic contaminants in environmental waters via UV irradiation or chemical oxidation: A dual-edged approach.
Sci Total Environ
February 2025
Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou, 510006, China; Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Guangzhou, 510000, China.
OH-mediated advanced oxidation processes (AOPs) are widely used in wastewater treatment and drinking water purification. Recently, an increasing number of studies have indicated that common inorganic nitrogen ions can efficiently generate •OH under UV irradiation, demonstrating strong performance in the degradation of various contaminants. Conversely, the presence of inorganic nitrogen ions in UV or other oxidation processes dramatically increases the yield of toxic nitro (so)-aromatic products and the formation potential of nitrogenous disinfection by-products with high genotoxicity and cytotoxicity.
View Article and Find Full Text PDFFabrication of a novel reusable nanozyme by immobilizing Co-doped carbon dots on nanocellulose aerogels for efficient dyes degradation.
Int J Biol Macromol
January 2025
Institute of Forest Science, Kangwon National University, Chuncheon 24341, Republic of Korea; Department of Forest Biomaterials Engineering, College of Forest and Environmental Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:
Carbon dot-based nanozymes have gained significant attention, but their application in dye degradation remains limited due to low activity and challenges in recovery and reuse. To overcome these limitations, high peroxidase-active Co-doped carbon dots (CoCDs) with surface amines were synthesized via hydrothermal method and immobilized onto TEMPO-oxidized cellulose nanofibrils (TOCNF) aerogels using EDC/NHS coupling. For the first time, this study investigates the dye degradation efficiency of CDs nanozyme.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!