?The relative brevity of the main His bundle refractory period compared with that of the A-V node above, and the trifascicular system below, makes it likely that premature beats originating in the His bundle will encounter physiologic delay, or block in both antegrade and retrograde modes. Two clinical cases of junctional premature beats are presented, which demonstrate many facets of concealment (antegrade, retrograde and bidirectional). Hitherto unreported is a ventricular echo which was induced by a junctional premature beat, the antegrade concealment of which was due to functional trifascicular block.
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http://dx.doi.org/10.1016/s0022-0736(76)80016-7 | DOI Listing |
JACC Case Rep
November 2024
Division of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Marked first-degree atrioventricular block with a PR interval ≥500 ms is rare, leading to unusual P-wave placement. In this case, the P waves immediately after the QRS waves complicated rhythm interpretation. Close attention to P-wave morphology and fused premature ventricular complexes can be important for a proper diagnosis.
View Article and Find Full Text PDFPathol Res Pract
January 2025
Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, Oberdürrbacher Straße 6, Würzburg 97080, Germany. Electronic address:
Necrotizing enterocolitis (NEC) is a major cause of mortality in preterm infants. Its pathophysiology remains poorly understood but intestinal epithelial barrier dysfunction contributes to the disease. We characterized junctional proteins in intestinal specimens from preterm infants.
View Article and Find Full Text PDFBMJ Ment Health
November 2024
Department of Clinical, Neuro- and Developmental Psychology, World Health Organization Collaborating Center for Research and Dissemination of Psychological Interventions, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Background: Available empirical evidence on participant-level factors associated with dropout from psychotherapies for post-traumatic stress disorder (PTSD) is both limited and inconclusive. More comprehensive understanding of the various factors that contribute to study dropout from cognitive-behavioural therapy with a trauma focus (CBT-TF) is crucial for enhancing treatment outcomes.
Objective: Using an individual participant data meta-analysis (IPD-MA) design, we examined participant-level predictors of study dropout from CBT-TF interventions for PTSD.
Curr HIV Res
November 2024
Department of Cardiology, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, 100015, China.
Am J Med Genet A
November 2024
Department of Genetics, APHP-Robert Debré University Hospital, Paris, France; INSERM UMR1141, Neurodiderot, University of Paris Cité, Paris, France.
The RUBCN gene encodes a widely expressed protein called Rubicon, the main function of which is to negatively regulate macroautophagy. A single homozygous pathogenic variant of the RUBCN gene has been reported to date in two unrelated consanguineous Saudi families with spinocerebellar ataxia autosomal recessive 15 (OMIM#613516). This variant is responsible for the deletion of the highly conserved Rubicon Homology (RH) domain, which is important for the colocalization of Rubicon with Rab7 in the late endosome.
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