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Maintenance treatment of catatonia with benzodiazepines: A case series and literature review.
Neuropsychopharmacol Hung
December 2024
College of Medicine, University of Kentucky, Lexington, KY 40506, USA.
Objective: Benzodiazepines, particularly lorazepam, are good options for acute catatonia treatment. Published catatonia literature on benzodiazepine maintenance treatment and benzodiazepine tolerance is limited.
Methods: This is a chart review covering 30 years of clinical experience in the state of Kentucky, (United States of America), where there was no easy access to electroconvulsive therapy.
Initiation of Antipsychotics During the First Year After First-Episode Psychosis: A Population-Based Study.
Acta Psychiatr Scand
November 2024
Niuvanniemi Hospital, Kuopio, Finland.
Background: Antipsychotics are recommended after first-episode psychosis. Knowledge on the current use patterns in real-world settings is thus important to inform clinical practice. We aimed to describe antipsychotic initiation during 1 year after first-episode psychosis and its associated factors.
View Article and Find Full Text PDFManipulation of Lipid Nanocapsules as an Efficient Intranasal Platform for Brain Deposition of Clozapine as an Antipsychotic Drug.
Pharmaceutics
November 2024
Department of Pharmaceutics, Egyptian Drug Authority, Giza 12511, Egypt.
Background/objectives: The blood-brain barrier (BBB) significantly limits the treatment of central nervous system disorders, such as schizophrenia, by restricting drug delivery to the brain. This study explores the potential of intranasal clozapine-loaded lipid nanocapsules (IN LNCs) as a targeted and effective delivery system to the brain.
Methods: LNCs were prepared using the phase inversion technique and characterized in terms of size, zeta potential, entrapment efficiency (EE%), and in vitro drug release.
2001-2021 Comparative Persistence of Oral Antipsychotics in Patients Initiating Treatment: Superiority of Clozapine in Time-to-Treatment Discontinuation.
Pharmacopsychiatry
November 2024
Unit for Quality of Care and Rights Promotion in Mental Health, Department of Health Policy, Istituto di Ricerche Farmacologiche "Mario Negri" - IRCCS, Milan, Italy.
Background: Continuous antipsychotic (AP) therapy is crucial for managing psychotic disorders, and its early interruption reflects the drug's failure. Real-world epidemiological research is essential for confirming experimental data and generating new research hypotheses.
Methods: The persistence of oral APs in a large population sample from 2000 to 2021 was analyzed by comparing AP prescriptions over this period across four Italian provinces, using dispensing data linked via a record-linkage procedure among regional healthcare utilization databases.
Antipsychotic prescribing practices and their association with rehospitalization in a forensic psychiatric sample.
Front Psychiatry
October 2024
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Article Synopsis
- There is a lack of research on antipsychotic prescribing practices specifically for patients in forensic psychiatric services, despite extensive literature on their use in general psychiatric settings.
- The study involved 153 forensic psychiatric patients with psychotic illnesses, finding that the majority were middle-aged males, predominantly white, and had serious offenses, with 75.9% prescribed atypical antipsychotics.
- Rehospitalization rates were notable, with 52.9% of patients rehospitalized at least once; clozapine showed lower rehospitalization rates compared to other medications, indicating it may be underused and warrants further investigation.
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