AI Article Synopsis
- - ALL-1, a member of the human trithorax/Polycomb gene family, plays a role in acute leukemia and exists within a large multiprotein complex consisting of at least 29 proteins involved in transcription and chromatin remodeling.
- - The complex includes important transcription factors like TFIID and SWI/SNF, which help modify nucleosomes and histones through processes such as acetylation and methylation.
- - In particular, the ALL-1 SET domain is crucial for H3-K4 methylation activity, and chromatin immunoprecipitations indicate that ALL-1 is bound to the promoter of the Hox a9 gene, where histones are actively modified.
Article Abstract
ALL-1 is a member of the human trithorax/Polycomb gene family and is also involved in acute leukemia. ALL-1 is present within a stable, very large multiprotein supercomplex composed of > or =29 proteins. The majority of the latter are components of the human transcription complexes TFIID (including TBP), SWI/SNF, NuRD, hSNF2H, and Sin3A. Other components are involved in RNA processing or in histone methylation. The complex remodels, acetylates, deacetylates, and methylates nucleosomes and/or free histones. The complex's H3-K4 methylation activity is conferred by the ALL-1 SET domain. Chromatin immunoprecipitations show that ALL-1 and other complex components examined are bound at the promoter of an active ALL-1-dependent Hox a9 gene. In parallel, H3-K4 is methylated, and histones H3 and H4 are acetylated at this promoter.
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| http://dx.doi.org/10.1016/s1097-2765(02)00740-2 | DOI Listing |
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