We analyzed records of malaria therapy patients sequentially or simultaneously inoculated with Plasmodium falciparum and Plasmodium malariae. Gametocyte production was enhanced in P. falciparum by prior or concurrent P. malariae infection but diminished or unaffected in P. malariae by P. falciparum. Conversely, asexual-form production was diminished in P. malariae but unaffected in P. falciparum.
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http://dx.doi.org/10.4269/ajtmh.2002.67.411 | DOI Listing |
Pathogens
December 2024
Department of Epidemiology and Tropical Medicine, Military Institute of Medicine-National Research Institute, 128 Szaserów St., 04-141 Warsaw, Poland.
Malaria remains a major public health threat in Sub-Saharan Africa. According to the World Health Organization (WHO) estimates, species account for nearly 100% of the malaria cases occurring on the African continent. According to the Centers for Disease Control and Prevention (CDC), falciparum malaria predominates, but non-falciparum species are also present in Africa.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
Malaria Research and Training Center (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.
Plasmodium malariae is the third most prevalent human malaria parasite species and contributes significantly to morbidity. Nevertheless, our comprehension of this parasite's biology remains limited, primarily due to its frequent co-infections with other species and the lack of a continuous in vitro culture system. To effectively combat and eliminate this overlooked parasite, it is imperative to acquire a better understanding of this species.
View Article and Find Full Text PDFSci Rep
December 2024
Interdisciplinary Centre of Medical Research of Franceville (CIRMF), Franceville, Gabon.
Malaria is a significant public health challenge in Gabon, with high prevalence rates in rural and semi-urban areas. This study investigated Plasmodium infection prevalence among outpatients at a medical laboratory in Franceville, Gabon, in 2020. Data from 500 patients were analyzed, revealing an overall infection rate of 33.
View Article and Find Full Text PDFNat Commun
December 2024
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Plasmodium malariae parasites are widely observed across the tropics and sub-tropics. This slow-growing species, known to maintain chronic asymptomatic infections, has been associated with reduced antimalarial susceptibility. We analyse 251 P.
View Article and Find Full Text PDFTissue Cell
December 2024
Department of Electronics and Computer Engineering, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310 UTM, Malaysia.
Malaria is endemic in poverty-stricken regions of the world, and most diagnosis reveal comorbidity with other infectious diseases some of which manifest as a deformity of the structural arrangement of the Red Blood Cells (RBCs) during thin blood smear microscopy. This common occurring deformity is termed rouleaux formation, and it is the stacking together of RBCs like chains of coins. The presence of rouleaux formation indicates either a bacterial infection, connective tissue disease, chronic liver disease, multiple myeloma or diabetes among others, it is a highly common occurrence in malaria infected patients and according to the international council for standardization of hematology (ICSH), microscopists are mandated to report its presence.
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