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Kaposi Sarcoma Associated with Tofacitinib Use in a Patient with Rheumatoid Arthritis.
R I Med J (2013)
August 2023
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI.
Kaposi sarcoma is a rare vascular malignancy associated with HHV-8 infection. Four variants of Kaposi sarcoma have been described: Classic, African, HIV-associated, and iatrogenic. Iatrogenic Kaposi sarcoma is typically associated with immunosuppression and organ transplantation.
View Article and Find Full Text PDFTreatments for AIDS/HIV-related Kaposi sarcoma: A systematic review of the literature.
Int J Dermatol
November 2022
Department of Dermatology, Singapore General Hospital, Singapore, Singapore.
Background: Treatment guidelines are not well established in AIDS-related Kaposi sarcoma (KS).
Objective: We aim to review the evidence on efficacy of treatments for AIDS-related Kaposi sarcoma.
Methods: We searched the Cochrane Library, PubMed, and Embase Database from date of database inception till July 2020.
Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics.
Toxicol Lett
November 2017
Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic. Electronic address:
The main intention of this study was the investigation of impact of natural biologically active ligands of nuclear retinoid/retinoid X receptors (all-trans and 9-cis retinoic acid) on proteomic pattern in human estrogen receptor negative breast cancer cell line MDA-MB-231. For this purpose, proteomic strategies based on bottom-up method were applied. The total cell proteins were extracted utilizing a commercially Radio-Immunoprecipitation Assay (RIPA) buffer and separated on 2D sodium dodecyl sulfate polyacrylamide gel electrophoresis (2D SDS-PAGE).
View Article and Find Full Text PDFAlitretinoin in Dermatology-An Update.
Indian J Dermatol
November 2015
Department of Dermatology, Sri Ramachandra University, Chennai, Tamil Nadu, India.
Alitretinoin is a pan retinoic acid agonist. It was initially used as 0.1% gel in the management of localized Kaposi's sarcoma.
View Article and Find Full Text PDFRXR agonist modulates TR: corepressor dissociation upon 9-cis retinoic acid treatment.
Mol Endocrinol
February 2015
Centro Nacional de Pesquisa em Energia e Materiais (J.F., J.L.O.C., T.R.D., L.M.A., M.T.V., J.X.-N., A.C.M.F.), Laboratório Nacional de Biociências, Campinas SP, 13083-970, Brazil; and Instituto de Física de São Carlos (I.P.), Universidade de São Paulo, São Carlos SP, 13560-970, Brazil.
Transcriptional regulation controlled by thyroid hormone receptor (TR) drives events such as development, differentiation, and metabolism. TRs may act either as homodimers or as heterodimers with retinoid X receptor (RXR). Thyroid hormone T3 preferentially binds TR-RXR heterodimers, which activate transcription through coactivator recruitment.
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