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Long-term outcomes of corneal transplantation: a review of 8,378 patients.
BMC Ophthalmol
January 2025
Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Kargar Street, Tehran, Iran.
Purpose: To analyze the outcomes of corneal transplantation procedures over a 13-year period at Farabi Eye Hospital, Tehran, Iran, to identify trends and determinants influencing the frequency and success of primary and re-transplantations.
Methods: Utilizing a comprehensive dataset from the hospital's Hospital Information System, the study reviewed the records of 8,378 patients who underwent corneal transplants between 2009 and 2022. This analysis included demographic information, surgical details, and follow-up data.
Heart Transplantation Outcomes for Fontan Patients When Using Contemporary Strategies: Heart-Liver Transplantation and Ventricular Assist Device Therapy.
World J Pediatr Congenit Heart Surg
January 2025
The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Background: With an increasing number of Fontan patients surviving into adulthood, the burden of end-stage heart failure is increasing. Prior studies have reported suboptimal heart transplantation (HTx) outcomes. Therefore, the authors describe their institutional experience of HTx in patients with Fontan circulation failure, including heart-liver transplantation (HLTx) and pretransplant systemic ventricular assist device (SVAD) therapies.
View Article and Find Full Text PDFThe small-for-size syndrome in living donor liver transplantation: current management.
Updates Surg
October 2024
Department of Liver Transplantation, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Small-for-size syndrome poses a significant challenge in living donor liver transplantation, with potentially severe consequences including liver failure and death. This review explores the management strategies for SFSS, starting from the pathophysiology of the disease. SFSS arises from insufficient liver mass in the graft and hyperdynamic circulation in cirrhotic recipients, leading to portal hyperperfusion and subsequent liver injury.
View Article and Find Full Text PDFmiRNA biomarkers to predict risk of primary non-function of fatty allografts and drug induced acute liver failures.
Mol Cell Biochem
October 2024
Hannover Medical School, Centre for Pharmacology and Toxicology, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Primary non-function (PNF) of an allograft defines an irreversible graft failure and although rare, constitutes a life-threatening condition that requires high-urgency re-transplantation. Equally, drug induced acute liver failures (ALF) are seldom but the rapid loss of hepatic function may require orthotropic liver transplantation (OLT). Recently, we reported the development of a rodent PNF-disease model of fatty allografts and showed that a dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of PNF.
View Article and Find Full Text PDFBeyond Immunity: Challenges in Kidney Retransplantation Among Persons Living With HIV.
J Surg Res
November 2024
Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania; Department of Surgery, Temple University Hospital, Philadelphia, Pennsylvania. Electronic address:
Article Synopsis
- This study examines kidney retransplantation (re-KT) outcomes specifically comparing HIV-positive (HIV+) and HIV-negative (HIV-) patients from 2014 to 2022.
- The research shows that HIV+ recipients face higher risks of graft loss due to factors like being more likely to be Black, experiencing delayed graft function, and having significant HLA mismatches.
- The findings indicate a need for better organ matching and strategies to improve re-KT success in HIV+ patients, as they exhibited significantly lower graft survival rates overall.
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