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The right ventricle explains sex differences in survival in idiopathic pulmonary arterial hypertension.
Chest
June 2014
Department of Pulmonology. Electronic address:
Background: Male sex is an independent predictor of worse survival in pulmonary arterial hypertension (PAH). This finding might be explained by more severe pulmonary vascular disease, worse right ventricular (RV) function, or different response to therapy. The aim of this study was to investigate the underlying cause of sex differences in survival in patients treated for PAH.
View Article and Find Full Text PDFEvaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy--a possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats?
Exp Toxicol Pathol
November 2006
Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.
Spontaneous valvulopathy has been described as nodular or segmental thickenings composed of fibromyxoid tissue in the subendocardium of various valve-leaflets in aging rats, but its pathogenesis and significance are incompletely understood. In this study, we examined the 5-hydroxytryptamine 2B receptor (5HT2BR) expression and characterization of extracellular matrix (ECM) components, and related these to the presence of valvulopathy in the mitral valve-leaflet (spontaneous mitral valvulopathy, SMV) of Sprague-Dawley (SD) rats. We also examined hearts from Fischer 344 (F344) rats treated with dl-amphetamine sulfate for 103 weeks to further explore the potential for drug-induced exacerbation of SMV.
View Article and Find Full Text PDFMorphology of anorexigen-associated valve disease by transthoracic and transesophageal echocardiography.
Am J Cardiol
December 2002
Oregon Health Sciences University, Portland, Oregon, USA.
Quantitative analysis of human heart valves: does anorexigen exposure produce a distinctive morphological lesion?
Cardiovasc Pathol
February 2003
University of British Columbia, McDonald Research Laboratories, Room 292, 1081 Burrard Street, Vancouver, BC, Canada, V6Z1Y6.
The need for more detail regarding the clinical and morphological features of human heart valves has become evident due to recent controversy regarding anorexigen-associated valvular dysfunction. In the present study, we used quantitative digital image analysis of geometric and compositional features to compare the histopathology of cardiac valves excised from patients treated with anorexigens as compared to normal, floppy, rheumatic and carcinoid valves. Anorexigen-exposed valves had the greatest number of onlays/valve (P<.
View Article and Find Full Text PDFThe pathobiology of pulmonary hypertension. Endothelium.
Clin Chest Med
September 2001
Departments of Pathology, and Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA.
Dysfunctional endothelial cells have a central and critical role in the initiation and progression of severe pulmonary hypertension. The elucidation of the mechanisms involved in the control of endothelial cell proliferation and cell death in the pulmonary vasculature, therefore, is fundamentally important in the pathogenesis of severe pulmonary hypertension and of great interest for a better understanding of endothelial cell biology. Because the intravascular growth of endothelial cells resulting in tumorlets is unique to severe pulmonary hypertension, this phenomenon can teach researchers about the factors involved in the formation and maintenance of the normal endothelial cell monolayer.
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