AI Article Synopsis
- Antiphospholipid antibodies (aPL) are diverse immunoglobulins that specifically target phospholipids and certain proteins, with key examples including beta2 glycoprotein I and prothrombin.
- Current detection methods for these antibodies involve standard immunoassays, like those for anticardiolipin antibodies.
- While a clear link exists between anticardiolipin antibodies and thrombosis, their specific role in causing strokes and whether they are independent risk factors for stroke in the general population is still not fully understood.
Article Abstract
Antiphospholipid (aPL) antibodies are a wide and heterogeneous group of closely related immunoglobulins that have specificity for a number of phospholipids (PLs), PL-binding proteins, including beta2 glycoprotein I (beta2GP1), prothrombin, and PL-protein complexes. Antiphospholipid antibodies are currently detected by a standard solid-phase immunoassay such as anticardiolipin (aCL) antibodies. Although the association between aCL antibodies and thrombosis is well recognized, their role in stroke pathogenesis, and the possibility that they are an independent stroke risk factors in the general stroke population, remains to be determined. There are other negatively charged PL, largely represented within the cellular membrane and involved in the coagulation. Different studies have demonstrated a positive correlation among other aPL and stroke.
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| http://dx.doi.org/10.1081/ceh-120015327 | DOI Listing |
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