[Effects of acute moderate hypoxia on plasma angiotensin II and adrenomedullin in pilots].

Objective. To study the effect of acute moderate hypoxia on plasma angiotensin II (AII) and adrenomedullin (ADM) content in pilots. Method. The concentration of plasma AII and ADM was measured by radioimmunoassay in 16 healthy male pilots in the early morning (6:00), following acute moderate hypoxic exposure (10:00) and 6 h after returned to the ground (16:00). Sixteen healthy male ground crews were set as control group, and their plasma AII and ADM content was assayed at corresponding time. Result. 1) Plasma AII and ADM content of pilot group and that of the control group was not different (P>0.05). 2) Plasma AII and ADM content immediately after acute moderate hypoxic exposure in the pilot group was significantly higher than that of before hypoxia (P<0.05), and it returned to normal level 6 h after hypoxia. Conclusion. Acute moderate hypoxia can induce temporarily increase of plasma AII and ADM in pilots.