The therapeutic interest of gemcitabine both as a single drug and in combination is now well known and applied in various malignant diseases. However, it would be worth being further explored in two tumor models for which its efficacy has been suspected and which have been somehow "abandoned" by modern oncology after the demonstration of their high sensitivity to platinum derivatives, namely epidermoid tumours of the upper aero-digestive tract and uterine cervix. Combination studies should be encouraged in this setting.
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