AI Article Synopsis
- Major events in the cell cycle, such as DNA synthesis and mitosis, are regulated by a network of protein interactions that control cyclin-dependent kinases.
- Computer simulations help compare theoretical models with experimental data but don’t reveal the qualitative dynamics of how molecular interactions influence cell replication.
- Bifurcation diagrams provide insights into the cell cycle's dynamics, checkpoint roles, and how mutations can disrupt normal cell cycle regulation, as shown in studies of fission yeast.
Article Abstract
Major events of the cell cycle--DNA synthesis, mitosis and cell division-are regulated by a complex network of protein interactions that control the activities of cyclin-dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. Computer simulations are necessary for detailed quantitative comparisons between theory and experiment, but they give little insight into the qualitative dynamics of the control system and how molecular interactions determine the fundamental physiological properties of cell replication. To that end, bifurcation diagrams are a useful analytical tool, providing new views of the dynamical organization of the cell cycle, the role of checkpoints in assuring the integrity of the genome, and the abnormal regulation of cell cycle events in mutants. These claims are demonstrated by an analysis of cell cycle regulation in fission yeast.
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| http://dx.doi.org/10.1002/bies.10191 | DOI Listing |
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